Eyelid Occlusion induced Form Deprivation Myopia (FDM) on Axial Length and Morphological Changes of the Sclera in Rabbits

Rini Kusumawardhany, GatutSuhendro, Tjahjono D. Gondhowiardjo, Nurwasis, Atina Yustisia Lestari, LitaRakhmaYustinasari

Research output: Contribution to journalArticle

Abstract

The aim of the research was to induce form deprivation myopia (FDM) and to investigate the axial length and morphological changes of the sclera. Eight rabbits were monocularly deprived by occlusion the right eyelids for 4 weeks as (FDM group): the left eye served as an untreated contralateral control group. Axial length was measured by A-scan biometry. The scleral thickness and scleral fibroblast were evaluated by light microscopy. Statistical analysis using a paired t-test showed that axial length post-treatment (p =0.004) in FDM group was significantly longer than those of the contralateral eyes. Significant reduction in the scleral thickness (p<0.000) and the scleral fibroblast (p<0.001) was noticed in FDM group compared with the control. In conclusion, eyelid occlusion could be validated to induce form-deprivation myopia model in rabbit and the sclera plays an important role in the induction of myopia.

Original languageEnglish
Pages (from-to)38-40
Number of pages3
JournalIndian Veterinary Journal
Volume96
Issue number10
Publication statusPublished - 1 Jan 2019

Keywords

  • Eyelid occlusion deprivation myopia, rabbit

Fingerprint Dive into the research topics of 'Eyelid Occlusion induced Form Deprivation Myopia (FDM) on Axial Length and Morphological Changes of the Sclera in Rabbits'. Together they form a unique fingerprint.

  • Cite this

    Kusumawardhany, R., GatutSuhendro, Gondhowiardjo, T. D., Nurwasis, Lestari, A. Y., & LitaRakhmaYustinasari (2019). Eyelid Occlusion induced Form Deprivation Myopia (FDM) on Axial Length and Morphological Changes of the Sclera in Rabbits. Indian Veterinary Journal, 96(10), 38-40.