Extraction of vitexin from binahong (Anredera cordifolia (Ten.) Steenis) leaves using betaine - 1,4 butanediol natural deep eutectic solvent (NADES)

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Abstract

The leaves of binahong (Anredera cordifolia (Ten) Steenis) contain flavonoids as bioactive substances that have efficacy to treat wounds and diseases caused by bacteria. One of the flavonoids contained in the leaves is 8-glucopyranosyl-4'5'7-trihydroxyflavone or vitexin. Conventional extraction of flavonoids from leaves of binahong has been developed and usually using non-friendly organic solvent. To overcome these problems, a Natural Deep Eutectic Solvent (NADES) is used to replace the conventional organic solvents, as it is an environmentally friendly, non-toxic and high boiling point solvent. In this study, a betaine-based NADES combined with 1,4-butanediol in 1:3 mole ratio was used as the extraction solvent. Vitexin in the extract was analyzed qualitatively and quantitatively using an HPLC. The extraction of vitexin from binahong leaves at room temperature (27°C) for four hours give yield of 46 ppm, much lower than 200 ppm yield obtained after extraction at 55°C for 90 minutes. This results showed that (a) NADES consisting of betaine and 1,4 butanediol is a promising green solvent for extraction of vitexin from binahong leaves, and, (b) the extraction can be performed above ambient temperature, as long as it does not exceed the degradation temperature of the bioactive compound extracted.

Original languageEnglish
Title of host publicationInternational Conference on Chemistry, Chemical Process and Engineering, IC3PE 2017
EditorsIs Fatimah, Gani Purwiandono
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735414914
DOIs
Publication statusPublished - 17 Mar 2017
EventInternational Conference on Chemistry, Chemical Process and Engineering, IC3PE 2017 - Yogyakarta, Indonesia
Duration: 15 Nov 201616 Nov 2016

Publication series

NameAIP Conference Proceedings
Volume1823
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

ConferenceInternational Conference on Chemistry, Chemical Process and Engineering, IC3PE 2017
Country/TerritoryIndonesia
CityYogyakarta
Period15/11/1616/11/16

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