TY - JOUR
T1 - Extended spectrum beta-lactamase-producing Escherichia coli surveillance in the human, food chain, and environment sectors
T2 - Tricycle project (pilot) in Indonesia
AU - Puspandari, Nelly
AU - Sunarno, Sunarno
AU - Febrianti, Tati
AU - Febriyana, Dwi
AU - Saraswati, Ratih Dian
AU - Rooslamiati, Indri
AU - Amalia, Novi
AU - Nursofiah, Sundari
AU - Hartoyo, Yudi
AU - Herna, Herna
AU - Mursinah, Mursinah
AU - Muna, Fauzul
AU - Aini, Nurul
AU - Risniati, Yenni
AU - Dhewantara, Pandji Wibawa
AU - Allamanda, Puttik
AU - Wicaksana, Dwi Nawang
AU - Sukoco, Rinto
AU - Efadeswarni,
AU - Nelwan, Erni Juwita
AU - Cahyarini,
AU - Haryanto, Budi
AU - Sihombing, Benyamin
AU - Soares Magalhães, Ricardo J.
AU - Kakkar, Manish
AU - Setiawaty, Vivi
AU - Matheu, Jorge
N1 - Funding Information:
This study was funded by WHO Country Grant . The writers would like to especially thank Agus Suprapto, Siswanto, Pretty Multihartina, Rita Marleta Dewi, Kambang Sariadji, colleagues from Jatinegara Primary Health Care and East Jakarta Municipal Health Office , Director of Centre for Research and Development for Environmental Quality and Laboratory , Head of Disease Investigation Center Subang , collagues from Directorate of Referral Health Service Ministry of Health , colleagues from Directorate General of Livestock and Animal Health Service for their continuous assistance and support. The great thank Heike Schmitt, Jaap Wagenaar, FAO and WHO Indonesia Team , and all teams of the Global and Regional Tricycle Project.
Funding Information:
This study was funded by WHO Country Grant. The writers would like to especially thank Agus Suprapto, Siswanto, Pretty Multihartina, Rita Marleta Dewi, Kambang Sariadji, colleagues from Jatinegara Primary Health Care and East Jakarta Municipal Health Office, Director of Centre for Research and Development for Environmental Quality and Laboratory, Head of Disease Investigation Center Subang, collagues from Directorate of Referral Health Service Ministry of Health, colleagues from Directorate General of Livestock and Animal Health Service for their continuous assistance and support. The great thank Heike Schmitt, Jaap Wagenaar, FAO and WHO Indonesia Team, and all teams of the Global and Regional Tricycle Project.
Publisher Copyright:
© 2021 The Authors
PY - 2021/12
Y1 - 2021/12
N2 - The World Health Organization (WHO) has been implementing antimicrobial surveillance with a “One Health” approach, known as the Global Surveillance ESBL E. coli Tricycle Project. We describe the implementation of the Tricycle Project (pilot) in Indonesia, focusing on its results, challenges and recommendations. The samples were 116 patients with bloodstream infections caused by ESBL E. coli, 100 rectal swabs collected from pregnant women, 240 cecums of broiler, and 119 environmental samples, using the standardized method according to the guidelines. ESBL-producing E. coli was found in 40 (40%) of the 100 pregnant women, while the proportion of ESBL-producing E. coli was 57.7% among the total E. coli-induced bloodstream infections. ESBL-producing E. coli was isolated from 161 (67.1%) out of 240 broilers. On the other hand, the average concentration of E. coli in the water samples was 2.0 × 108 CFU/100 mL, and the ratio of ESBL-producing E. coli was 12.8% of total E. coli. Unfortunately, 56.7% of questionnaires for patients were incomplete. The Tricycle Project (pilot) identified that the proportion of ESBL-producing E. coli was very high in all types of samples, and several challenges and obstacles were encountered during the implementation of the study in Indonesia. The finding of this study have implication to health/the antimicrobial resistance (AMR) surveillance. We recommend continuing this project and extending this study to other provinces to determine the AMR burden as the baseline in planning AMR control strategies in Indonesia. We also recommend improving the protocol of this study to minimize obstacles in the field.
AB - The World Health Organization (WHO) has been implementing antimicrobial surveillance with a “One Health” approach, known as the Global Surveillance ESBL E. coli Tricycle Project. We describe the implementation of the Tricycle Project (pilot) in Indonesia, focusing on its results, challenges and recommendations. The samples were 116 patients with bloodstream infections caused by ESBL E. coli, 100 rectal swabs collected from pregnant women, 240 cecums of broiler, and 119 environmental samples, using the standardized method according to the guidelines. ESBL-producing E. coli was found in 40 (40%) of the 100 pregnant women, while the proportion of ESBL-producing E. coli was 57.7% among the total E. coli-induced bloodstream infections. ESBL-producing E. coli was isolated from 161 (67.1%) out of 240 broilers. On the other hand, the average concentration of E. coli in the water samples was 2.0 × 108 CFU/100 mL, and the ratio of ESBL-producing E. coli was 12.8% of total E. coli. Unfortunately, 56.7% of questionnaires for patients were incomplete. The Tricycle Project (pilot) identified that the proportion of ESBL-producing E. coli was very high in all types of samples, and several challenges and obstacles were encountered during the implementation of the study in Indonesia. The finding of this study have implication to health/the antimicrobial resistance (AMR) surveillance. We recommend continuing this project and extending this study to other provinces to determine the AMR burden as the baseline in planning AMR control strategies in Indonesia. We also recommend improving the protocol of this study to minimize obstacles in the field.
KW - Antimicrobial resistance
KW - ESBL-producing E. coli
KW - Indonesia
KW - One health
UR - http://www.scopus.com/inward/record.url?scp=85122673608&partnerID=8YFLogxK
U2 - 10.1016/j.onehlt.2021.100331
DO - 10.1016/j.onehlt.2021.100331
M3 - Article
AN - SCOPUS:85122673608
SN - 2352-7714
VL - 13
JO - One Health
JF - One Health
M1 - 100331
ER -
