Extended release of dexamethasone from PLA/PLGA nanoparticles modified with a cationic surfactant

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Abstract

Long-term drug release is needed to treat ocular diseases, especially in the posterior region where the retina is located. Dexamethasone, an anti-inflammation drug, was encapsulated in biocompatible and biodegradable polylactic acid/polylactic-co-glycolic acid (PLA, PLGA 90:10, PLGA 50:50) nanoparticles prepared using the solvent evaporation method. The surface of the nanoparticles was modified with didodecyldimethylammonium bromide (DDAB), a cationic surfactant, to increase the residence time in the vitreous, by contacting the nanoparticles with various surfactant solutions (PVA, DDAB-1%, PVA-DDAB-0.5%, PVA-DDAB-1%). Those modified using DDAB-1% solution exhibit the highest positive zeta potential (52.7±9.3 mV) and the smallest particle size (329±44 nm). Dexamethasone released into a buffer release media (45°C, 100 rpm) from nanoparticles with higher lactic acid content (PLA and PLGA 90:10) showed zero- order release profile up to 48 days with 30-70% accumulative release. On the other hand, the DDAB release profiles show that after 6-12 days, the cationic surfactant was detached from the surface of the nanoparticles.

Original languageEnglish
Title of host publication5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
Subtitle of host publicationProceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020
EditorsKenny Lischer, Sugeng Supriadi, Siti Fauziyah Rahman, Yudan Whulanza
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735440869
DOIs
Publication statusPublished - 23 Mar 2021
Event5th International Symposium of Biomedical Engineering, ISBE 2020 - Depok, Virtual, Indonesia
Duration: 28 Jul 202029 Jul 2020

Publication series

NameAIP Conference Proceedings
Volume2344
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference5th International Symposium of Biomedical Engineering, ISBE 2020
CountryIndonesia
CityDepok, Virtual
Period28/07/2029/07/20

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