Expression of Sox genes in tooth development

Katsushige Kawasaki; Maiko Kawasaki; Momoko Watanabe; Erik Idrus; Takahiro Nagai; Shelly Oommen; Takeyasu Maeda; Nobuko Hagiwara; Jianwen Que; Paul T. Sharpe; Atsushi Ohazama

doi:10.1387/ijdb.150192ao

Expression of Sox genes in tooth development

Katsushige Kawasaki, Maiko Kawasaki, Momoko Watanabe, Erik Idrus, Takahiro Nagai, Shelly Oommen, Takeyasu Maeda, Nobuko Hagiwara, Jianwen Que, Paul T. Sharpe, Atsushi Ohazama

Department of Oral Biology

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Members of the Sox gene family play roles in many biological processes including organogenesis. We carried out comparative in situ hybridization analysis of seventeen sox genes (Sox1-14, 17, 18, 21) during murine odontogenesis from the epithelial thickening to the cytodifferentiation stages. Localized expression of five Sox genes (Sox6, 9, 13, 14 and 21) was observed in tooth bud epithelium. Sox13 showed restricted expression in the primary enamel knots. At the early bell stage, three Sox genes (Sox8, 11, 17 and 21) were expressed in pre-ameloblasts, whereas two others (Sox5 and 18) showed expression in odontoblasts. Sox genes thus showed a dynamic spatio-temporal expression during tooth development.

Original language	English
Pages (from-to)	471-478
Number of pages	8
Journal	International Journal of Developmental Biology
Volume	59
Issue number	10-12
DOIs	https://doi.org/10.1387/ijdb.150192ao
Publication status	Published - 1 Jan 2015

Keywords

In situ hybridization
Sox
Tooth development

Access to Document

10.1387/ijdb.150192ao

Cite this

@article{6c29dc50b54c43a998660067cc311774,

title = "Expression of Sox genes in tooth development",

abstract = "Members of the Sox gene family play roles in many biological processes including organogenesis. We carried out comparative in situ hybridization analysis of seventeen sox genes (Sox1-14, 17, 18, 21) during murine odontogenesis from the epithelial thickening to the cytodifferentiation stages. Localized expression of five Sox genes (Sox6, 9, 13, 14 and 21) was observed in tooth bud epithelium. Sox13 showed restricted expression in the primary enamel knots. At the early bell stage, three Sox genes (Sox8, 11, 17 and 21) were expressed in pre-ameloblasts, whereas two others (Sox5 and 18) showed expression in odontoblasts. Sox genes thus showed a dynamic spatio-temporal expression during tooth development.",

keywords = "In situ hybridization, Sox, Tooth development",

author = "Katsushige Kawasaki and Maiko Kawasaki and Momoko Watanabe and Erik Idrus and Takahiro Nagai and Shelly Oommen and Takeyasu Maeda and Nobuko Hagiwara and Jianwen Que and Sharpe, {Paul T.} and Atsushi Ohazama",

note = "Publisher Copyright: {\textcopyright} 2015 UBC Press.",

year = "2015",

month = jan,

day = "1",

doi = "10.1387/ijdb.150192ao",

language = "English",

volume = "59",

pages = "471--478",

journal = "International Journal of Developmental Biology",

issn = "0214-6282",

publisher = "University of the Basque Country Press",

number = "10-12",

}

TY - JOUR

T1 - Expression of Sox genes in tooth development

AU - Kawasaki, Katsushige

AU - Kawasaki, Maiko

AU - Watanabe, Momoko

AU - Idrus, Erik

AU - Nagai, Takahiro

AU - Oommen, Shelly

AU - Maeda, Takeyasu

AU - Hagiwara, Nobuko

AU - Que, Jianwen

AU - Sharpe, Paul T.

AU - Ohazama, Atsushi

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Members of the Sox gene family play roles in many biological processes including organogenesis. We carried out comparative in situ hybridization analysis of seventeen sox genes (Sox1-14, 17, 18, 21) during murine odontogenesis from the epithelial thickening to the cytodifferentiation stages. Localized expression of five Sox genes (Sox6, 9, 13, 14 and 21) was observed in tooth bud epithelium. Sox13 showed restricted expression in the primary enamel knots. At the early bell stage, three Sox genes (Sox8, 11, 17 and 21) were expressed in pre-ameloblasts, whereas two others (Sox5 and 18) showed expression in odontoblasts. Sox genes thus showed a dynamic spatio-temporal expression during tooth development.

AB - Members of the Sox gene family play roles in many biological processes including organogenesis. We carried out comparative in situ hybridization analysis of seventeen sox genes (Sox1-14, 17, 18, 21) during murine odontogenesis from the epithelial thickening to the cytodifferentiation stages. Localized expression of five Sox genes (Sox6, 9, 13, 14 and 21) was observed in tooth bud epithelium. Sox13 showed restricted expression in the primary enamel knots. At the early bell stage, three Sox genes (Sox8, 11, 17 and 21) were expressed in pre-ameloblasts, whereas two others (Sox5 and 18) showed expression in odontoblasts. Sox genes thus showed a dynamic spatio-temporal expression during tooth development.

KW - In situ hybridization

KW - Sox

KW - Tooth development

UR - http://www.scopus.com/inward/record.url?scp=84961374865&partnerID=8YFLogxK

U2 - 10.1387/ijdb.150192ao

DO - 10.1387/ijdb.150192ao

M3 - Article

C2 - 26864488

AN - SCOPUS:84961374865

SN - 0214-6282

VL - 59

SP - 471

EP - 478

JO - International Journal of Developmental Biology

JF - International Journal of Developmental Biology

IS - 10-12

ER -

Expression of Sox genes in tooth development

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this