Expression of p27Kip1 and E-cadherin in head and neck squamous cell carcinoma of Indonesian patients

Elza Ibrahim; V. Joewono; Diah Rini Handjari; Agoeng Tjahajani Sarwono; A. W. Suhartono; K. Eto; M. A. Ikeda

doi:10.2174/1874210601408010136

Expression of p27^Kip1 and E-cadherin in head and neck squamous cell carcinoma of Indonesian patients

Elza Ibrahim, V. Joewono, Diah Rini Handjari, Agoeng Tjahajani Sarwono, A. W. Suhartono, K. Eto, M. A. Ikeda

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Cancer cells exhibit characteristic damage of DNA and its expression. The expression of the tumor suppressors E-cadherin and p27^Kip1 has been tested on 57 head and neck squamous cell carcinomas (HNSCC) of Indonesian subjects. HNSCC tumor samples including both primary and (unrelated) nodal cases were obtained from the archives of Indonesian hospitals, in accordance with acknowledged ethical requirements. Only modest correlation was found between reduced expression of E-cadherin or p27^Kip1 with increased malignancy of primary and nodal growth. The observed strong correlation regardless of malignancy between the expressed levels of E-cadherin and p27^Kip1 suggests that also in combination these would not help to better predict the outcome of HNSCC.

Original language	English
Pages (from-to)	136-143
Number of pages	8
Journal	Open Dentistry Journal
Volume	8
Issue number	1
DOIs	https://doi.org/10.2174/1874210601408010136
Publication status	Published - 2014

Keywords

E-cadherin
Head and neck squamous cell carcinoma
p27

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10.2174/1874210601408010136

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abstract = "Cancer cells exhibit characteristic damage of DNA and its expression. The expression of the tumor suppressors E-cadherin and p27Kip1 has been tested on 57 head and neck squamous cell carcinomas (HNSCC) of Indonesian subjects. HNSCC tumor samples including both primary and (unrelated) nodal cases were obtained from the archives of Indonesian hospitals, in accordance with acknowledged ethical requirements. Only modest correlation was found between reduced expression of E-cadherin or p27Kip1 with increased malignancy of primary and nodal growth. The observed strong correlation regardless of malignancy between the expressed levels of E-cadherin and p27Kip1 suggests that also in combination these would not help to better predict the outcome of HNSCC.",

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AU - Ibrahim, Elza

AU - Joewono, V.

AU - Handjari, Diah Rini

AU - Sarwono, Agoeng Tjahajani

AU - Suhartono, A. W.

AU - Eto, K.

AU - Ikeda, M. A.

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N2 - Cancer cells exhibit characteristic damage of DNA and its expression. The expression of the tumor suppressors E-cadherin and p27Kip1 has been tested on 57 head and neck squamous cell carcinomas (HNSCC) of Indonesian subjects. HNSCC tumor samples including both primary and (unrelated) nodal cases were obtained from the archives of Indonesian hospitals, in accordance with acknowledged ethical requirements. Only modest correlation was found between reduced expression of E-cadherin or p27Kip1 with increased malignancy of primary and nodal growth. The observed strong correlation regardless of malignancy between the expressed levels of E-cadherin and p27Kip1 suggests that also in combination these would not help to better predict the outcome of HNSCC.

AB - Cancer cells exhibit characteristic damage of DNA and its expression. The expression of the tumor suppressors E-cadherin and p27Kip1 has been tested on 57 head and neck squamous cell carcinomas (HNSCC) of Indonesian subjects. HNSCC tumor samples including both primary and (unrelated) nodal cases were obtained from the archives of Indonesian hospitals, in accordance with acknowledged ethical requirements. Only modest correlation was found between reduced expression of E-cadherin or p27Kip1 with increased malignancy of primary and nodal growth. The observed strong correlation regardless of malignancy between the expressed levels of E-cadherin and p27Kip1 suggests that also in combination these would not help to better predict the outcome of HNSCC.

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Expression of p27^Kip1 and E-cadherin in head and neck squamous cell carcinoma of Indonesian patients

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Keywords

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