TY - JOUR
T1 - Expression of HBsAg and HBcAg in liver biopsy specimens of chronic b hepatitis patients and its relation with histology activity index
AU - Tanurahardja, Budiana
AU - Esti Soetrisno, B.
AU - Endardjo, Sutjahjo
AU - Tjahjadi, Gunawan
AU - Marwoto, Wirasmi
N1 - Publisher Copyright:
© 1996. Faculty of Medicine, Universitas Indonesia. All right reserved.
PY - 1996/7/1
Y1 - 1996/7/1
N2 - To assess the relationship between Histology Activitiy Index (HAI) and the expression of HBsAg and HBcAg. Thirty liver biopsy specimens of chronic B hepatitis patients have been examined Expression of HBsAg and HBcAg were determined by immunoperoxidase staining. HAI was calculated according to Knodell's method. All of the specimens (29) were positive for HBsAg and HBcAg staining. Regular-uniform distribution patterns of HBsAg were found in 3 specimens and irregular non-uniform patterns in 26 specimens. Regular-uniform patterns of HBcAg were found in 4 specimens and the irregular non-uniform patterns in 25 specimens. HBsAgs 1 + were seen in all specimens which have HAI range of 1 to 18. Cytoplasmic/membraneous HBcAgs were seen 1+ in 20 specimens, 2+ in 3 specimens, and 3+ in 6 specimens. HAI of each group which showed HBcAg was not significantly different. HBcAgs in the nuclei of liver cells were seen 1+in 14 specimens, and 15 specimens were negative. HAI of each of these groups showed no significant differences. HAI of regular-uniform distribution pattern groups of HBsAg and HBcAg were not significantly different from HAI of irregular non-uniform groups. Expression of HBsAg and HBcAg in liver biopsy specimens of chronic B hepatitis patients are not correlated with necroinflammatory activity.
AB - To assess the relationship between Histology Activitiy Index (HAI) and the expression of HBsAg and HBcAg. Thirty liver biopsy specimens of chronic B hepatitis patients have been examined Expression of HBsAg and HBcAg were determined by immunoperoxidase staining. HAI was calculated according to Knodell's method. All of the specimens (29) were positive for HBsAg and HBcAg staining. Regular-uniform distribution patterns of HBsAg were found in 3 specimens and irregular non-uniform patterns in 26 specimens. Regular-uniform patterns of HBcAg were found in 4 specimens and the irregular non-uniform patterns in 25 specimens. HBsAgs 1 + were seen in all specimens which have HAI range of 1 to 18. Cytoplasmic/membraneous HBcAgs were seen 1+ in 20 specimens, 2+ in 3 specimens, and 3+ in 6 specimens. HAI of each group which showed HBcAg was not significantly different. HBcAgs in the nuclei of liver cells were seen 1+in 14 specimens, and 15 specimens were negative. HAI of each of these groups showed no significant differences. HAI of regular-uniform distribution pattern groups of HBsAg and HBcAg were not significantly different from HAI of irregular non-uniform groups. Expression of HBsAg and HBcAg in liver biopsy specimens of chronic B hepatitis patients are not correlated with necroinflammatory activity.
KW - Expression of HBsAg and HBcAg
KW - Histology activity index
KW - Necroinflammatory activity
UR - http://www.scopus.com/inward/record.url?scp=85008627050&partnerID=8YFLogxK
U2 - 10.13181/mji.v5i3.861
DO - 10.13181/mji.v5i3.861
M3 - Article
AN - SCOPUS:85008627050
SN - 0853-1773
VL - 5
SP - 142
EP - 148
JO - Medical Journal of Indonesia
JF - Medical Journal of Indonesia
IS - 3
ER -
