Expression of HBsAg and HBcAg in liver biopsy specimens of chronic b hepatitis patients and its relation with histology activity index

Budiana Tanurahardja, B. Esti Soetrisno, Sutjahjo Endardjo, Gunawan Tjahjadi, Wirasmi Marwoto

Research output: Contribution to journalArticle

Abstract

To assess the relationship between Histology Activitiy Index (HAI) and the expression of HBsAg and HBcAg. Thirty liver biopsy specimens of chronic B hepatitis patients have been examined Expression of HBsAg and HBcAg were determined by immunoperoxidase staining. HAI was calculated according to Knodell's method. All of the specimens (29) were positive for HBsAg and HBcAg staining. Regular-uniform distribution patterns of HBsAg were found in 3 specimens and irregular non-uniform patterns in 26 specimens. Regular-uniform patterns of HBcAg were found in 4 specimens and the irregular non-uniform patterns in 25 specimens. HBsAgs 1 + were seen in all specimens which have HAI range of 1 to 18. Cytoplasmic/membraneous HBcAgs were seen 1+ in 20 specimens, 2+ in 3 specimens, and 3+ in 6 specimens. HAI of each group which showed HBcAg was not significantly different. HBcAgs in the nuclei of liver cells were seen 1+in 14 specimens, and 15 specimens were negative. HAI of each of these groups showed no significant differences. HAI of regular-uniform distribution pattern groups of HBsAg and HBcAg were not significantly different from HAI of irregular non-uniform groups. Expression of HBsAg and HBcAg in liver biopsy specimens of chronic B hepatitis patients are not correlated with necroinflammatory activity.

Original languageEnglish
Pages (from-to)142-148
Number of pages7
JournalMedical Journal of Indonesia
Volume5
Issue number3
Publication statusPublished - 1 Jul 1996

Keywords

  • Expression of HBsAg and HBcAg
  • Histology activity index
  • Necroinflammatory activity

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