Expression of CA-125 Level and Neutrophil to Lymphocyte Ratio in Infected and Non-infected Endometrioma

Introduction. Implantation and growth of endometriosis was determined by immune cell. There were several immunologic cells that promoting implantation and cell proliferation such as macrophages, Natural killer, lymphocyte and monocyte. Infected endometrioma was associated in women with revised American Society for Reproductive Medicine (ASRM) stage III-IV. Neutrophil lymphocyte ratio (NLR) was a simple systemic inflammation response markers. The sensitivity and specificity CA-125 in predicting endometrioma was very low but it had been used to monitor the progress of endometriosis. Therefore, measuring mean in leucocyte, NLR, PLR and CA-125 level in infected endometrioma was necessary. Material & Method. A retrospective study from medical record between January 2014-December 2014 that was diagnosed as endometriosis cyst and undergone either laparotomy and laparoscopy. Result. The mean of age 39.42±7.35, leukocyte 9,209,77±3,310,14, The mean and SD of each variables were in group infected WBC 16,433.33±7,277.13, NLR 11.04±9.63, PLR 342.13±156.23, CA-125 342.13±156.23 CA-125 adjunct to the NLR 2332.74±1,872.31.. The mean and SD of each variables were in group non infected WBC 8,475.27±2485.59, NLR 4.04±4.49, and CA-125 adjunct to the 981,99±1,229.55. This was correlate to the infection process. Conclusion. Increasing level of WBC, neutrophil, NLR and NLR adjunct CA-125 are different in infected endometrioma and non-infected endometrioma. The increasing level of those was due to response of the bacteria. However, endometriosis did not show cell immune to eliminate instead providing its cell to growth.