TY - JOUR
T1 - Expression levels of Ki-67 and cyclin D1 in advanced nasopharyngeal carcinoma and its prognosis
AU - Cahyanur, Rahmat
AU - Irawan, Cosphiadi
AU - Lisnawati, null
AU - Yunus, Reyhan Eddy
AU - Adham, Marlinda
N1 - Funding Information:
This work is supported by Penelitian Dasar Unggulan Perguruan Tinggi (PDUPT) Grant 2021– 2022 number NKB-130/UN2.RST/HKP.05.00/2021 and funded by the Ministry of Research and Technology of Republic of Indonesia, National Research, and Innovation Agency.
Publisher Copyright:
© 2023, Indian Association of Biomedical Scientists. All rights reserved.
PY - 2023/3/28
Y1 - 2023/3/28
N2 - Introduction and Aim: Nasopharyngeal cancer (NPC) prognosis has been associated with cyclin D1 and Ki-67. These tumor markers had never been tested in NPC patients in Indonesia before. Therefore, this study aims to evaluate the relationships between Ki-67 and cyclin D1 expression levels and the clinicopathological features of nasopharyngeal cancer (NPC) patients. Materials and Methods: During the years 2015 until 2018, thirty-one nasopharyngeal cancer patients were studied in a cohort study at RSUPN Dr. Cipto Mangunkusumo. Patients aged ≥18 years, diagnosed with NPC according to the histopathological results, metastasis NPC, Eastern Cooperative Oncology Group 0–1, and those who had completed first-line chemotherapy treatment with 5–fluorouracil were included in this study. The Ki-67 and cyclin D1 expression levels were evaluated with the h-score. The NLR values were collected prior to the treatment. The 2-year survival rate was analyzed based on the optimal cut-off value obtained. The optimal cut-off values of Ki-67 and cyclin D1 were categorized into high-and low-expression groups to observe the 2-year mortality. Results: The relationships between Ki-67 and cyclin D1, clinical, pathological, and prognosis of patients were examined. Patients with Ki-67 high expression had a worse 2-year survival rate than those with low expression (p<0.05). Ki-67 expression was found to be significantly related to adverse outcomes (p<0.05, OR: 41.107, 95% CI: 2.600–649.940), while the cyclin D1 expression was not significantly related to adverse outcomes (p>0.05). Conclusion: Ki-67 expression was associated with poor prognosis in NPC patients. Nevertheless, further research is required to explore the specific mechanism of cyclin D1 expression in NPC prognosis.
AB - Introduction and Aim: Nasopharyngeal cancer (NPC) prognosis has been associated with cyclin D1 and Ki-67. These tumor markers had never been tested in NPC patients in Indonesia before. Therefore, this study aims to evaluate the relationships between Ki-67 and cyclin D1 expression levels and the clinicopathological features of nasopharyngeal cancer (NPC) patients. Materials and Methods: During the years 2015 until 2018, thirty-one nasopharyngeal cancer patients were studied in a cohort study at RSUPN Dr. Cipto Mangunkusumo. Patients aged ≥18 years, diagnosed with NPC according to the histopathological results, metastasis NPC, Eastern Cooperative Oncology Group 0–1, and those who had completed first-line chemotherapy treatment with 5–fluorouracil were included in this study. The Ki-67 and cyclin D1 expression levels were evaluated with the h-score. The NLR values were collected prior to the treatment. The 2-year survival rate was analyzed based on the optimal cut-off value obtained. The optimal cut-off values of Ki-67 and cyclin D1 were categorized into high-and low-expression groups to observe the 2-year mortality. Results: The relationships between Ki-67 and cyclin D1, clinical, pathological, and prognosis of patients were examined. Patients with Ki-67 high expression had a worse 2-year survival rate than those with low expression (p<0.05). Ki-67 expression was found to be significantly related to adverse outcomes (p<0.05, OR: 41.107, 95% CI: 2.600–649.940), while the cyclin D1 expression was not significantly related to adverse outcomes (p>0.05). Conclusion: Ki-67 expression was associated with poor prognosis in NPC patients. Nevertheless, further research is required to explore the specific mechanism of cyclin D1 expression in NPC prognosis.
KW - Cyclin D1
KW - Ki-67
KW - nasopharyngeal cancer
KW - neutrophil-to-lymphocyte ratio
KW - prognosis
UR - http://www.scopus.com/inward/record.url?scp=85167912734&partnerID=8YFLogxK
U2 - 10.51248/.V43I01.2021
DO - 10.51248/.V43I01.2021
M3 - Article
AN - SCOPUS:85167912734
SN - 0970-2067
VL - 43
SP - 492
EP - 498
JO - Biomedicine (India)
JF - Biomedicine (India)
IS - 1
ER -