[Exposure to nanoparticle-rich diesel exhaust may cause liver damage].

Yuki Ito, Doni Hikmat Ramdhan, Yukie Yanagiba, Nozomi Yamagishi, Michihiro Kamijima, Tamie Nakajima

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)


Diesel exhaust (DE) is one of the air pollutants in the world, and exposure to DE is an environmental health concern. Most studies amongst the limited number of studies on hepatotoxicity have focused on genotoxicity or mutagenicity. However, DE exposure may cause liver damage because one prospective study suggests that DE exposure is associated with increased mortality due to arteriosclerosis and cirrhosis of the liver. Peroxisome proliferator-activated receptor (PPAR) α plays a role in the regulation of lipid homeostasis and inflammation and thereby may be involved in the progression of atherosclerosis. We investigated whether nanoparticle-rich diesel exhaust (NR-DE) affects the liver and how PPARα is involved in the NR-DE induced effects. We report these results briefly in this minireview. Our results suggest NR-DE-induced hepatic inflammation and dyslipidemia. PPARα may be involved in the development of these disorders.

Original languageEnglish
Pages (from-to)638-642
Number of pages5
JournalNihon eiseigaku zasshi. Japanese journal of hygiene
Issue number4
Publication statusPublished - 2011


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