Expert consensus on the diagnosis and treatment of end-stage liver disease complicated by infections

Tao Chen, Guang Chen, Guiqiang Wang, Sombat Treeprasertsuk, Cosmas Rinaldi Adithya Lesmana, Han Chieh Lin, Mamun Al-mahtab, Yogesh K. Chawla, Soek Siam Tan, Jia Horng Kao, Man Fung Yuen, Guan Huei Lee, Diana Alcantara-Payawal, Nobuaki Nakayama, Zaigham Abbas, Wasim Jafri, Dong Joon Kim, Ashok Choudhury, Rakhi Mahiwall, Jinlin HouSaeed Hamid, Jidong Jia, J. S. Bajaj, Fusheng Wang, Shiv K. Sarin, Qin Ning

Research output: Contribution to journalArticlepeer-review


End-stage liver disease (ESLD) is a life-threatening clinical syndrome and when complicated with infection the mortality is markedly increased. In patients with ESLD, bacterial or fungal infection can induce or aggravate the occurrence or progression of liver decompensation. Consequently, infections are among the most common complications of disease deterioration. There is an overwhelming need for standardized protocols for early diagnosis and appropriate management for patients with ESLD complicated by infections. Asia Pacific region has the largest number of ESLD patients, due to hepatitis B and the growing population of alcohol and NAFLD. Concomitant infections not only add to organ failure and high mortality but also to financial and healthcare burdens. This consensus document assembled up-to-date knowledge and experience from colleagues across the Asia–Pacific region, providing data on the principles as well as evidence-based current working protocols and practices for the diagnosis and treatment of patients with ESLD complicated by infections.

Original languageEnglish
JournalHepatology International
Publication statusAccepted/In press - 2024


  • ACLF
  • Acute decompensation
  • Antibiotics
  • Cirrhosis
  • Consensus
  • Decompensation
  • Infection
  • Organ failure
  • Sepsis
  • Septic shock
  • Treatment


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