Experience with the once - daily calcium antagonist amlodipine on 24 - hour ambulatory blood pressure in hypertensive patients

The antihypertensive efficacy and tolerability of once-daily calcium antagonist amlodipine (5-10 mg) were studied in 20 patients with mild to moderate hypertension. 24-hour ambulatory blood pressure monitoring in conjunction with sphygmomanometric measurement were used to study the effects of amlodipine. 24-hour ambulatory blood pressure monitoring made after 8 weeks of treatment with amlodipine revealed that amlodipine effectively reduced blood pressure throughout the whole 24-h period without altering the normal circadian pattern.