Experience of the first 6 years of pediatric kidney transplantation in Indonesia: A multicenter retrospective study

Cahyani Gita Ambarsari, Eka Laksmi Hidayati, Partini Pudjiastuti Trihono, Meilania Saraswati, Arry Rodjani, Irfan Wahyudi, Gerhard Reinaldi Situmorang, Jon Jin Kim, Omega Mellyana, Agustina Kadaristiana

Research output: Contribution to journalArticle

Abstract

Background: Pediatric kidney transplantation was only introduced in Indonesia in 2013. We therefore aimed to assess the characteristics and outcomes of transplants performed from its inception to January 2019. Method: The study had a dual-center retrospective design. We examined the records of kidney transplant recipients and then calculated patient and graft survival rates by Kaplan-Meier survival analysis with 95% confidence intervals (95% CI). Results: In total, 12 kidney transplantations were performed in eleven children during the study period; among these, ten were boys, and nine had renal failure caused by congenital anomaly of the kidney or urinary tract. All donors were living, and all recipients were on dialysis at the time of transplantation, when their median age was 14.5 years (range, 8-19 years). Three patients died of infection in the first year of follow-up and two lost their allograft by the time of their last follow-up (median, 13 months; range, 4-69 months). The 1-year patient survival rate was therefore 68.18% (95% CI, 29.72%-88.61%), which remained unchanged at 3 and 5 years. However, the non-death-censored graft survival rates at 1, 3, and 5 years were 68.18% (95% CI, 29.72%-88.61%), 51.14% (95% CI, 14.5%-79.46%), and 25.57% (95% CI, 1.38%-64.78%), respectively. Conclusion: Patient and graft survival rates after pediatric kidney transplantation in Indonesia are lower than those reported in other countries. Closer patient follow-up and stricter adherence to guidelines could improve transplant outcomes, but we must seek to improve the balance between infection and rejection.

Original languageEnglish
JournalPediatric Transplantation
DOIs
Publication statusAccepted/In press - 2020

Keywords

  • graft rejection
  • graft survival
  • living donor
  • retrospective study

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