Expanding japanese encephalitis vaccination to selected endemic indonesia provinces: A cost-effectiveness analysis

Soewarta Kosen, Levina Chandra Khoe, Endang Indriasih, Ingan Tarigan, Retno Widyastuti Iriawan, Rozana Ika Agustiya, G. William Letson, Elisabeth Vodicka

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: A Markov model was used to evaluate the potential health and economic impact of introducing JE vaccine nationally and in selected endemic areas of Indonesia compared to no vaccination from government and societal perspectives over a child's lifetime horizon. Methods: Costs were obtained from hospitalized JE suspected patient billing data from 2014 to 2019 in seven provinces. Local data burden data were derived from the literature. Analysis considered several scenarios, including national and sub-regional introduction in seven provinces via a one-time vaccination campaign in all children 1–15 years old followed by routine immunization among infants (RI), or RI alone without vaccination campaign. Results and discussions: Across scenarios, JE vaccination was projected to range from cost-saving to cost-effective compared to no vaccination at a willingness-to-pay threshold of 0.5x gross domestic product per capita. Including a one-time campaign would avert nearly three times as many JE cases and deaths compared to RI alone while still providing good value for money.

Original languageEnglish
Article number100179
JournalVaccine: X
Volume11
DOIs
Publication statusPublished - Aug 2022

Keywords

  • Cost-effectiveness
  • Expanding JE vaccination
  • Indonesia
  • Japanese encephalitis

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