Evaluation of the Ethyl Acetate Extract of the Roots of Avicennia marina as Potential Anticancer Drug

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


In this modern age cancer is still a prevalent disease. Even with advancements of technology, current treatments for cancer still have various side-effects that sometimes create more harm to the patient. A complete solution for cancer is still not found yet. Recently, mangroves were shown to be promising sources of new drugs. The species Avicennia marina was suggested to be anti-cancerous, thus it could be a potential anticancer drug. This study was conducted to evaluate the viability of A. marina root ethyl acetate extract as a possible anticancer drug, and to determine whether its anticancer mechanisms are by counteracting the reactive oxygen species as an antioxidant. The extract was subjected to total phenolic and flavonoid content tests, to determine the bioactive compounds, which are thought to be directly related to antioxidant activities. The DPPH method was used to evaluate the antioxidant activity of the extract. Brine shrimp (Artemia salina) was subjected to the extract to determine its toxicity, and determined its anticancer properties against cancer cell lines HT29 (colon), HeLa (cervix) and T47D (breast) by MTT Assay. Results showed that the extract has moderate amounts of phenolic and flavonoids, moderate antioxidant activity, not toxic to normal cells but toxic towards cancer cells.

Original languageEnglish
Title of host publicationProceedings of the 6th International Conference of Food, Agriculture, and Natural Resource
PublisherAtlantis Press
ISBN (Print)978-94-6239-506-0
Publication statusPublished - 5 Jan 2022


Dive into the research topics of 'Evaluation of the Ethyl Acetate Extract of the Roots of Avicennia marina as Potential Anticancer Drug'. Together they form a unique fingerprint.

Cite this