Evaluation of pore forming agent effect and drug loading process on hydrogel semi-IPN chitosan-methyl cellulose in a floating drug delivery system

Emil Budianto, S. Pamungkas

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Amoxicilin have a short residence time which is caused by the influence of gastric emptying. Floating drug delivery system as a resolve for amoxcicilin in combating bacterial Helicobacter pylory have been synthesized based on semi-IPN hydrogel chitosan-methyl cellulose containing pore forming agent (PFA) KHCO3 and K2CO3. Characterizations of the hydrogel were carried out by using Fourier Transform Infrared Spectroscopy (FTIR), UV-Vis spectrophotometry, and stereo optical microscope. Overall, KHCO3 in hydrogels showed a faster floating lag time (12m 41s) than K2CO3 (14m 40s) and both have a floating time of more than 3 hours. Based on floating ability evaluation, the optimum composition of PFA in hydrogel was KHCO3 20%. The comparison results between optimum composition in this research and optimum composition from previous research (used PFA CaCO3 15%) with the same drug loading process (in situ) showed that KHCO3 in hydrogel have a higher encapsulation efficiency and more controlled drug release profile than CaCO3 in hydrogel, namely 79% & 72% for encapsulation efficiency of KHCO3 20% and CaCO3 15%, respectively. The comparison results of drug loading process with the same PFA in the in situ loading drug process showed a higher encapsulation efficiency and more controlled drug release profile than the post loading drug process.

Original languageEnglish
Title of host publicationProceedings of the 3rd International Symposium on Current Progress in Mathematics and Sciences 2017, ISCPMS 2017
EditorsRatna Yuniati, Terry Mart, Ivandini T. Anggraningrum, Djoko Triyono, Kiki A. Sugeng
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735417410
DOIs
Publication statusPublished - 22 Oct 2018
Event3rd International Symposium on Current Progress in Mathematics and Sciences 2017, ISCPMS 2017 - Bali, Indonesia
Duration: 26 Jul 201727 Jul 2017

Publication series

NameAIP Conference Proceedings
Volume2023
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference3rd International Symposium on Current Progress in Mathematics and Sciences 2017, ISCPMS 2017
CountryIndonesia
CityBali
Period26/07/1727/07/17

Keywords

  • Chitosan, methyl cellulose
  • Floating Drug Delivery System (FDDS)
  • KCO
  • KHCO
  • in situ & post loading

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  • Cite this

    Budianto, E., & Pamungkas, S. (2018). Evaluation of pore forming agent effect and drug loading process on hydrogel semi-IPN chitosan-methyl cellulose in a floating drug delivery system. In R. Yuniati, T. Mart, I. T. Anggraningrum, D. Triyono, & K. A. Sugeng (Eds.), Proceedings of the 3rd International Symposium on Current Progress in Mathematics and Sciences 2017, ISCPMS 2017 [020058] (AIP Conference Proceedings; Vol. 2023). American Institute of Physics Inc.. https://doi.org/10.1063/1.5064055