TY - GEN
T1 - Evaluation of pore forming agent effect and drug loading process on hydrogel semi-IPN chitosan-methyl cellulose in a floating drug delivery system
AU - Budianto, E.
AU - Pamungkas, S.
N1 - Funding Information:
The authors would like to thank Universitas Indonesia for supporting our research financially through Publikasi Internasional Terindeks untuk Tugas Akhir (PITTA Grant.
Publisher Copyright:
© 2018 Author(s).
PY - 2018/10/22
Y1 - 2018/10/22
N2 - Amoxicilin have a short residence time which is caused by the influence of gastric emptying. Floating drug delivery system as a resolve for amoxcicilin in combating bacterial Helicobacter pylory have been synthesized based on semi-IPN hydrogel chitosan-methyl cellulose containing pore forming agent (PFA) KHCO3 and K2CO3. Characterizations of the hydrogel were carried out by using Fourier Transform Infrared Spectroscopy (FTIR), UV-Vis spectrophotometry, and stereo optical microscope. Overall, KHCO3 in hydrogels showed a faster floating lag time (12m 41s) than K2CO3 (14m 40s) and both have a floating time of more than 3 hours. Based on floating ability evaluation, the optimum composition of PFA in hydrogel was KHCO3 20%. The comparison results between optimum composition in this research and optimum composition from previous research (used PFA CaCO3 15%) with the same drug loading process (in situ) showed that KHCO3 in hydrogel have a higher encapsulation efficiency and more controlled drug release profile than CaCO3 in hydrogel, namely 79% & 72% for encapsulation efficiency of KHCO3 20% and CaCO3 15%, respectively. The comparison results of drug loading process with the same PFA in the in situ loading drug process showed a higher encapsulation efficiency and more controlled drug release profile than the post loading drug process.
AB - Amoxicilin have a short residence time which is caused by the influence of gastric emptying. Floating drug delivery system as a resolve for amoxcicilin in combating bacterial Helicobacter pylory have been synthesized based on semi-IPN hydrogel chitosan-methyl cellulose containing pore forming agent (PFA) KHCO3 and K2CO3. Characterizations of the hydrogel were carried out by using Fourier Transform Infrared Spectroscopy (FTIR), UV-Vis spectrophotometry, and stereo optical microscope. Overall, KHCO3 in hydrogels showed a faster floating lag time (12m 41s) than K2CO3 (14m 40s) and both have a floating time of more than 3 hours. Based on floating ability evaluation, the optimum composition of PFA in hydrogel was KHCO3 20%. The comparison results between optimum composition in this research and optimum composition from previous research (used PFA CaCO3 15%) with the same drug loading process (in situ) showed that KHCO3 in hydrogel have a higher encapsulation efficiency and more controlled drug release profile than CaCO3 in hydrogel, namely 79% & 72% for encapsulation efficiency of KHCO3 20% and CaCO3 15%, respectively. The comparison results of drug loading process with the same PFA in the in situ loading drug process showed a higher encapsulation efficiency and more controlled drug release profile than the post loading drug process.
KW - Chitosan, methyl cellulose
KW - Floating Drug Delivery System (FDDS)
KW - KCO
KW - KHCO
KW - in situ & post loading
UR - http://www.scopus.com/inward/record.url?scp=85056081806&partnerID=8YFLogxK
U2 - 10.1063/1.5064055
DO - 10.1063/1.5064055
M3 - Conference contribution
AN - SCOPUS:85056081806
T3 - AIP Conference Proceedings
BT - Proceedings of the 3rd International Symposium on Current Progress in Mathematics and Sciences 2017, ISCPMS 2017
A2 - Yuniati, Ratna
A2 - Mart, Terry
A2 - Anggraningrum, Ivandini T.
A2 - Triyono, Djoko
A2 - Sugeng, Kiki A.
PB - American Institute of Physics Inc.
T2 - 3rd International Symposium on Current Progress in Mathematics and Sciences 2017, ISCPMS 2017
Y2 - 26 July 2017 through 27 July 2017
ER -