Amoxicilin have a short residence time which is caused by the influence of gastric emptying. Floating drug delivery system as a resolve for amoxcicilin in combating bacterial Helicobacter pylory have been synthesized based on semi-IPN hydrogel chitosan-methyl cellulose containing pore forming agent (PFA) KHCO3 and K2CO3. Characterizations of the hydrogel were carried out by using Fourier Transform Infrared Spectroscopy (FTIR), UV-Vis spectrophotometry, and stereo optical microscope. Overall, KHCO3 in hydrogels showed a faster floating lag time (12m 41s) than K2CO3 (14m 40s) and both have a floating time of more than 3 hours. Based on floating ability evaluation, the optimum composition of PFA in hydrogel was KHCO3 20%. The comparison results between optimum composition in this research and optimum composition from previous research (used PFA CaCO3 15%) with the same drug loading process (in situ) showed that KHCO3 in hydrogel have a higher encapsulation efficiency and more controlled drug release profile than CaCO3 in hydrogel, namely 79% & 72% for encapsulation efficiency of KHCO3 20% and CaCO3 15%, respectively. The comparison results of drug loading process with the same PFA in the in situ loading drug process showed a higher encapsulation efficiency and more controlled drug release profile than the post loading drug process.