@inproceedings{64a6c86b9805484486d0cb3a20e5f868,
title = "Evaluation of pore forming agent effect and drug loading process on hydrogel semi-IPN chitosan-methyl cellulose in a floating drug delivery system",
abstract = "Amoxicilin have a short residence time which is caused by the influence of gastric emptying. Floating drug delivery system as a resolve for amoxcicilin in combating bacterial Helicobacter pylory have been synthesized based on semi-IPN hydrogel chitosan-methyl cellulose containing pore forming agent (PFA) KHCO3 and K2CO3. Characterizations of the hydrogel were carried out by using Fourier Transform Infrared Spectroscopy (FTIR), UV-Vis spectrophotometry, and stereo optical microscope. Overall, KHCO3 in hydrogels showed a faster floating lag time (12m 41s) than K2CO3 (14m 40s) and both have a floating time of more than 3 hours. Based on floating ability evaluation, the optimum composition of PFA in hydrogel was KHCO3 20%. The comparison results between optimum composition in this research and optimum composition from previous research (used PFA CaCO3 15%) with the same drug loading process (in situ) showed that KHCO3 in hydrogel have a higher encapsulation efficiency and more controlled drug release profile than CaCO3 in hydrogel, namely 79% & 72% for encapsulation efficiency of KHCO3 20% and CaCO3 15%, respectively. The comparison results of drug loading process with the same PFA in the in situ loading drug process showed a higher encapsulation efficiency and more controlled drug release profile than the post loading drug process.",
keywords = "Chitosan, methyl cellulose, Floating Drug Delivery System (FDDS), KCO, KHCO, in situ & post loading",
author = "E. Budianto and S. Pamungkas",
note = "Publisher Copyright: {\textcopyright} 2018 Author(s).; 3rd International Symposium on Current Progress in Mathematics and Sciences 2017, ISCPMS 2017 ; Conference date: 26-07-2017 Through 27-07-2017",
year = "2018",
month = oct,
day = "22",
doi = "10.1063/1.5064055",
language = "English",
series = "AIP Conference Proceedings",
publisher = "American Institute of Physics Inc.",
editor = "Ratna Yuniati and Terry Mart and Anggraningrum, {Ivandini T.} and Djoko Triyono and Sugeng, {Kiki A.}",
booktitle = "Proceedings of the 3rd International Symposium on Current Progress in Mathematics and Sciences 2017, ISCPMS 2017",
address = "United States",
}