TY - JOUR
T1 - Evaluation of mucin changes between daily and extended wear silicone hydrogel contact lenses
AU - Rhendy, Rio
AU - Rahayu, Tri
AU - Edwar, Lukman
AU - Sadikin, Mohamad
AU - Kekalih, Aria
N1 - Publisher Copyright:
© 2023 The Author(s). Licensee: AOSIS. This work is licensed under the Creative Commons Attribution License. All Rights Reserved.
PY - 2023
Y1 - 2023
N2 - Background: Initially, contact lenses were recommended only for daily wear because of infection and discomfort concerns. With rising demand, particularly for overnight use, extended wear lenses have gained significance. Despite concerns, intensive development of materials like Lotrafilcon B aims to meet this demand, focusing on comfort and safety. Aim: This study aimed to evaluate the mucin quantity and quality changes between daily and extended wear (Lotrafilcon B), impacting eye health and comfort. Setting: The study was conducted at Kirana Eye Center, Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Methods: This study was a single-blinded randomised clinical trial with two parallel groups. Forty (40) eligible subjects willingly participated. Mucin 5AC (MUC5AC) and Ferning-type tests were conducted. The 40 subjects with moderate myopia were then divided into a daily wear and an extended wear group. The MUC5AC test was performed at pre-fitting and at 4 weeks, whereas the Ferning-type tests were taken at pre-fitting and 1st and 4th weeks. Results: For both groups, there was a significant increase in MUC5AC levels from pre-fitting to week four, but with no significant difference between them in final MUC5AC levels. Additionally, the comparison of eyes with normal and abnormal Ferning-types between the two groups showed no significant differences at pre-fitting, 1st and 4th weeks. Conclusion: There is no significant difference in MUC5AC levels with the use of daily or extended wear (with Lotrafilcon B). Contribution: This study compares the impact of daily and extended wear Lotrafilcon B contact lenses on eye health and comfort in moderate myopia patients.
AB - Background: Initially, contact lenses were recommended only for daily wear because of infection and discomfort concerns. With rising demand, particularly for overnight use, extended wear lenses have gained significance. Despite concerns, intensive development of materials like Lotrafilcon B aims to meet this demand, focusing on comfort and safety. Aim: This study aimed to evaluate the mucin quantity and quality changes between daily and extended wear (Lotrafilcon B), impacting eye health and comfort. Setting: The study was conducted at Kirana Eye Center, Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Methods: This study was a single-blinded randomised clinical trial with two parallel groups. Forty (40) eligible subjects willingly participated. Mucin 5AC (MUC5AC) and Ferning-type tests were conducted. The 40 subjects with moderate myopia were then divided into a daily wear and an extended wear group. The MUC5AC test was performed at pre-fitting and at 4 weeks, whereas the Ferning-type tests were taken at pre-fitting and 1st and 4th weeks. Results: For both groups, there was a significant increase in MUC5AC levels from pre-fitting to week four, but with no significant difference between them in final MUC5AC levels. Additionally, the comparison of eyes with normal and abnormal Ferning-types between the two groups showed no significant differences at pre-fitting, 1st and 4th weeks. Conclusion: There is no significant difference in MUC5AC levels with the use of daily or extended wear (with Lotrafilcon B). Contribution: This study compares the impact of daily and extended wear Lotrafilcon B contact lenses on eye health and comfort in moderate myopia patients.
KW - contact lenses
KW - daily and extended wear lenses
KW - Ferning-type
KW - Lotrafilcon B
KW - MUC5AC
KW - myopia
UR - http://www.scopus.com/inward/record.url?scp=85193690447&partnerID=8YFLogxK
U2 - https://hdl.handle.net/10520/ejc-aveh_v83_n1_a884
DO - https://hdl.handle.net/10520/ejc-aveh_v83_n1_a884
M3 - Article
AN - SCOPUS:85193690447
SN - 2413-3183
VL - 83
JO - African Vision and Eye Health
JF - African Vision and Eye Health
IS - 1
M1 - a884
ER -