TY - JOUR
T1 - Evaluating the potential of NANOG as a glioma malignancy biomarker
AU - Runtu, F.
AU - Ichwan, S.
AU - Wanandi, S. I.
AU - Hardiany, N. S.
N1 - Publisher Copyright:
© 2018 Institute of Physics Publishing. All rights reserved.
PY - 2018/9/7
Y1 - 2018/9/7
N2 - To elucidate the role of NANOG in malignancy, the difference in relative expression of NANOG between low-and high-grade gliomas was evaluated. Gene quantification was performed using real-time reverse transcription polymerase chain reaction from 29 isolated RNA samples of glioma resected during the surgery of patients in the Neurosurgery Department of FKUI-RSCM. The relative expression of NANOG in low-and high-grade gliomas was analyzed for normality and compared statistically. Statistical analysis showed no significant difference in NANOG expression between low-and high-grade glioma although there was a tendency for higher expression in the latter. The results support the indication of NANOG as a malignancy biomarker. However, further studies of NANOG expression in malignancy using a greater sample size or other methods may help confirm its role as a cancer biomarker that could be used as a potential therapeutic target or prognosis indicator.
AB - To elucidate the role of NANOG in malignancy, the difference in relative expression of NANOG between low-and high-grade gliomas was evaluated. Gene quantification was performed using real-time reverse transcription polymerase chain reaction from 29 isolated RNA samples of glioma resected during the surgery of patients in the Neurosurgery Department of FKUI-RSCM. The relative expression of NANOG in low-and high-grade gliomas was analyzed for normality and compared statistically. Statistical analysis showed no significant difference in NANOG expression between low-and high-grade glioma although there was a tendency for higher expression in the latter. The results support the indication of NANOG as a malignancy biomarker. However, further studies of NANOG expression in malignancy using a greater sample size or other methods may help confirm its role as a cancer biomarker that could be used as a potential therapeutic target or prognosis indicator.
UR - http://www.scopus.com/inward/record.url?scp=85054522020&partnerID=8YFLogxK
U2 - 10.1088/1742-6596/1073/3/032057
DO - 10.1088/1742-6596/1073/3/032057
M3 - Conference article
AN - SCOPUS:85054522020
SN - 1742-6588
VL - 1073
JO - Journal of Physics: Conference Series
JF - Journal of Physics: Conference Series
IS - 3
M1 - 032057
T2 - 2nd Physics and Technologies in Medicine and Dentistry Symposium, PTMDS 2018
Y2 - 18 July 2018 through 18 July 2018
ER -
