Evaluating the potency of Sulawesi propolis compounds as ACE-2 inhibitors through molecular docking for COVID-19 drug discovery preliminary study

Apriliana Cahya Khayrani, Rafidha Irdiani, Reza Aditama, Diah Kartika Pratami, Kenny Lischer, Mohammad Javed Ansari, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Hesham S. Almoallim, Muhamad Sahlan

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Coronavirus disease (COVID-19) is a global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Up to date, there has been no specific cure to treat the disease. Indonesia is one of the countries that is still fighting to control virus transmission. Yet, at the same time, Indonesia has a rich biodiversity of natural medicinal products that potentially become an alternative cure. Thus, this study examined the potency of a natural medicinal product, Sulawesi propolis compounds produced by Tetragonula sapiens, inhibiting angiotensin-converting activity enzyme-2 (ACE-2), a receptor of SARS-CoV-2 in the human body. In this study, molecular docking was done to analyze the docking scores as the representation of binding affinity and the interaction profiles of propolis compounds toward ACE-2. The results illustrated that by considering the docking score and the presence of interaction with targeted sites, five compounds, namely glyasperin A, broussoflavonol F, sulabiroins A, (2S)-5,7-dihydroxy-4′-methoxy-8-prenylflavanone and isorhamnetin are potential to inhibit the binding of ACE-2 and SARS-CoV-2, with the docking score of −10.8, −9.9, −9.5, −9.3 and −9.2 kcal/mol respectively. The docking scores are considered to be more favorable compared to MLN-4760 as a potent inhibitor.

Original languageEnglish
Article number101297
JournalJournal of King Saud University - Science
Volume33
Issue number2
DOIs
Publication statusPublished - Mar 2021

Keywords

  • ACE-2
  • COVID-19
  • Molecular docking
  • Potent inhibitor
  • Sulawesi propolis

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