TY - JOUR
T1 - Estrogenic and acetylcholinesterase-enhancement activity of a new isoflavone, 7,2′,4′-trihydroxyisoflavone-4′-O-β-D- glucopyranoside from Crotalaria sessililflora
AU - Mun'im, Abdul
AU - Isoda, Hiroko
AU - Seki, Mariko
AU - Negishi, Osamu
AU - Ozawa, Tetsuo
PY - 2003/12/1
Y1 - 2003/12/1
N2 - A new isoflavone, 7,2′,4′-trihydroxyisoflavone-4′-O- β-D-glucopyranoside has been isolated from the aerial part of Crotalaria sessiliflora. The isoflavone glucoside enhanced the proliferation of the MCF-7 human breast cancer cell line, which possesses estrogen receptor (ER) and responds to estrogen in culture.The estrogenic property of the isoflavone glucoside was blocked by the known ER antagonist tamoxifen, indicating the involvement of the ER. Furthermore, the isoflavone glucoside was found to enhance the acetylcholinesterase (AChE) activity of the rat neuronal cell line PC12 at low concentrations of nerve growth factor (NGF).
AB - A new isoflavone, 7,2′,4′-trihydroxyisoflavone-4′-O- β-D-glucopyranoside has been isolated from the aerial part of Crotalaria sessiliflora. The isoflavone glucoside enhanced the proliferation of the MCF-7 human breast cancer cell line, which possesses estrogen receptor (ER) and responds to estrogen in culture.The estrogenic property of the isoflavone glucoside was blocked by the known ER antagonist tamoxifen, indicating the involvement of the ER. Furthermore, the isoflavone glucoside was found to enhance the acetylcholinesterase (AChE) activity of the rat neuronal cell line PC12 at low concentrations of nerve growth factor (NGF).
KW - 7,2′,4′-trihydroxyisoflavone-4′-O-β-D- glucopyranoside
KW - Crotalaria sessiliflora
KW - MCF-7 cell line
KW - PC12 neuronal cell line
KW - Phytoestrogen
UR - http://www.scopus.com/inward/record.url?scp=23944506771&partnerID=8YFLogxK
U2 - 10.1023/B:CYTO.0000039899.67160.18
DO - 10.1023/B:CYTO.0000039899.67160.18
M3 - Article
AN - SCOPUS:23944506771
SN - 0920-9069
VL - 43
SP - 127
EP - 134
JO - Cytotechnology
JF - Cytotechnology
IS - 1-3
ER -
