Estrogenic and acetylcholinesterase-enhancement activity of a new isoflavone, 7,2′,4′-trihydroxyisoflavone-4′-O-β-D- glucopyranoside from Crotalaria sessililflora

Abdul Mun'im; Hiroko Isoda; Mariko Seki; Osamu Negishi; Tetsuo Ozawa

doi:10.1023/B:CYTO.0000039899.67160.18

Estrogenic and acetylcholinesterase-enhancement activity of a new isoflavone, 7,2′,4′-trihydroxyisoflavone-4′-O-β-D- glucopyranoside from Crotalaria sessililflora

Abdul Mun'im, Hiroko Isoda, Mariko Seki, Osamu Negishi, Tetsuo Ozawa

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

A new isoflavone, 7,2′,4′-trihydroxyisoflavone-4′-O- β-D-glucopyranoside has been isolated from the aerial part of Crotalaria sessiliflora. The isoflavone glucoside enhanced the proliferation of the MCF-7 human breast cancer cell line, which possesses estrogen receptor (ER) and responds to estrogen in culture.The estrogenic property of the isoflavone glucoside was blocked by the known ER antagonist tamoxifen, indicating the involvement of the ER. Furthermore, the isoflavone glucoside was found to enhance the acetylcholinesterase (AChE) activity of the rat neuronal cell line PC12 at low concentrations of nerve growth factor (NGF).

Original language	English
Pages (from-to)	127-134
Number of pages	8
Journal	Cytotechnology
Volume	43
Issue number	1-3
DOIs	https://doi.org/10.1023/B:CYTO.0000039899.67160.18
Publication status	Published - 1 Dec 2003

Keywords

7,2′,4′-trihydroxyisoflavone-4′-O-β-D- glucopyranoside
Crotalaria sessiliflora
MCF-7 cell line
PC12 neuronal cell line
Phytoestrogen

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1023/B:CYTO.0000039899.67160.18

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title = "Estrogenic and acetylcholinesterase-enhancement activity of a new isoflavone, 7,2′,4′-trihydroxyisoflavone-4′-O-β-D- glucopyranoside from Crotalaria sessililflora",

abstract = "A new isoflavone, 7,2′,4′-trihydroxyisoflavone-4′-O- β-D-glucopyranoside has been isolated from the aerial part of Crotalaria sessiliflora. The isoflavone glucoside enhanced the proliferation of the MCF-7 human breast cancer cell line, which possesses estrogen receptor (ER) and responds to estrogen in culture.The estrogenic property of the isoflavone glucoside was blocked by the known ER antagonist tamoxifen, indicating the involvement of the ER. Furthermore, the isoflavone glucoside was found to enhance the acetylcholinesterase (AChE) activity of the rat neuronal cell line PC12 at low concentrations of nerve growth factor (NGF).",

keywords = "7,2′,4′-trihydroxyisoflavone-4′-O-β-D- glucopyranoside, Crotalaria sessiliflora, MCF-7 cell line, PC12 neuronal cell line, Phytoestrogen",

author = "Abdul Mun'im and Hiroko Isoda and Mariko Seki and Osamu Negishi and Tetsuo Ozawa",

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T1 - Estrogenic and acetylcholinesterase-enhancement activity of a new isoflavone, 7,2′,4′-trihydroxyisoflavone-4′-O-β-D- glucopyranoside from Crotalaria sessililflora

AU - Mun'im, Abdul

AU - Isoda, Hiroko

AU - Seki, Mariko

AU - Negishi, Osamu

AU - Ozawa, Tetsuo

PY - 2003/12/1

Y1 - 2003/12/1

N2 - A new isoflavone, 7,2′,4′-trihydroxyisoflavone-4′-O- β-D-glucopyranoside has been isolated from the aerial part of Crotalaria sessiliflora. The isoflavone glucoside enhanced the proliferation of the MCF-7 human breast cancer cell line, which possesses estrogen receptor (ER) and responds to estrogen in culture.The estrogenic property of the isoflavone glucoside was blocked by the known ER antagonist tamoxifen, indicating the involvement of the ER. Furthermore, the isoflavone glucoside was found to enhance the acetylcholinesterase (AChE) activity of the rat neuronal cell line PC12 at low concentrations of nerve growth factor (NGF).

AB - A new isoflavone, 7,2′,4′-trihydroxyisoflavone-4′-O- β-D-glucopyranoside has been isolated from the aerial part of Crotalaria sessiliflora. The isoflavone glucoside enhanced the proliferation of the MCF-7 human breast cancer cell line, which possesses estrogen receptor (ER) and responds to estrogen in culture.The estrogenic property of the isoflavone glucoside was blocked by the known ER antagonist tamoxifen, indicating the involvement of the ER. Furthermore, the isoflavone glucoside was found to enhance the acetylcholinesterase (AChE) activity of the rat neuronal cell line PC12 at low concentrations of nerve growth factor (NGF).

KW - 7,2′,4′-trihydroxyisoflavone-4′-O-β-D- glucopyranoside

KW - Crotalaria sessiliflora

KW - MCF-7 cell line

KW - PC12 neuronal cell line

KW - Phytoestrogen

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SN - 0920-9069

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JO - Cytotechnology

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ER -

Estrogenic and acetylcholinesterase-enhancement activity of a new isoflavone, 7,2′,4′-trihydroxyisoflavone-4′-O-β-D- glucopyranoside from Crotalaria sessililflora

Abstract

Keywords

UN SDGs

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