Estrogen Receptor b as A Potential Predictive Marker of Malignancy in Atypical Ductal Hyperplasia of The Breast

Agnes Stephanie Harahap, Endang Sri Roostini Hardianto, Primariadewi Rustamadji, Nurjati Chairani Siregar

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Estrogen receptor a (ER a) and estrogen receptor b (ER b) play a role in breastcancer progression through multistep carcinogenesis. Estrogen receptor b is a tumor supressorand its expression decreases during the tumor progression. Atypical ductal hyperplasia (ADH) is an intraductal proliferative lesion of the breast and has four to five times higher risk to become a carcinoma. The objective of this study is to obtain a marker that can predict malignant potential in ADH through expression of ER b.Methods: This is an analytic cross-sectional study using 24 cases of ADH without carcinoma and 24 cases of ADH with carcinoma. Estrogen receptor b status were assesed by immunohistochemistry and the H score.Results. ER b H score in ADH without carcinoma is significantly higher than ADH with carcinoma (p=0.006). ER b is catagorized as high if the H score >229.2.Conclusion: ER b can be used as a potential malignant predictive marker in ADH.
Original languageEnglish
JournalJournal of the Indonesian Medical Association : Majalah Kedokteran Indonesia
Publication statusPublished - 2012

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