Working ergonomically can reduce the risk of pain, increase the sense of comfort at work, reduce stress and cause increased productivity. However, working ergonomically has not been implemented maximally when working, especially people who work in the office, where the fact that skeletal muscle disorders are the biggest enemy of office workers, around 40 - 50% of workers report complaints. And worse conditions are predicted while working from home. Musculoskeletal Disorders (MSDs) related to work are disorders of the musculoskeletal system caused or exacerbated by the interaction of the work environment. Musculoskeletal Disorders can be caused by the contribution of various risk factors including individual factors, occupational or biomechanical factors and psychosocial factors. This study wanted to find out ergonomic risk factors and work styles for musculoskeletal disorders in students especially those carrying out distance learning. Structural Equation Modeling (SEM) method is used to process the Workstyle model with the addition of work posture factors, and musculoskeletal pain. Structural Equation Modeling (SEM) is a statistical method used to test the relationship between variables, such as between manifest and latent variables, the relationship between latent variables, and measuring measurement error variables on several independent and dependent variables in a model (Hair, 2010). The analysis was carried out by distributing questionnaires to 200 respondents. Respondents are shown to UI students who are carrying out distance learning and using laptops or computers while doing work / assignments. The results of the study indicate that there are several workstyle factors that contribute to student musculoskeletal disorders.