Textile and garment industry is one of the most important industries in the world. In Indonesia, the textile and garment industry is one of ten industries prioritized from the 2015-2035 Nation Industrial Development Master Plan (RIPIN). Job characteristics in the garment industry are generally material-handling processes and processes involving machinery that have high repetition that can cause Work-related Musculoskeletal Disorder (WMSD). WMSD is one of the biggest occupational health problems nowadays. In this research, workers of the screen printing division of garment industry Small Medium Enterprise (SME) has the highest risk in one of the SME in Jakarta. The workers were evaluated for their working postures using a posture evaluation index in a virtual environment in Jack simulation. The result shows that the worker has low injury to middle-low injury and middle-low injury to middle-high injury risk from their working postures. The repetitiveness of the work due to the high demand of the products, while there are only five workers available in the division and the awkward position of the workers while doing their work, is the cause of the probability of WMSD. Hierarchy of Control is used to prevent the risk of WMSD.