Epithelial mesenchymal transition in drug resistance and metastasis of lung cancer

Fariz Nurwidya, Fumiyuki Takahashi, Akiko Murakami, Kazuhisa Takahashi

Research output: Contribution to journalReview articlepeer-review

139 Citations (Scopus)

Abstract

Among all types of cancer, incidence of lung cancer remains the highest with regard to cancerrelated mortality. Problems contributing to recurrence of the disease include metastasis and drug resistance. Mounting evidence has demonstrated involvement of epithelial mesenchymal transition (EMT) in cancer progression. EMT is a critical mechanism ensuring tissue remodeling during morphogenesis of multicellular organisms. Therefore, understanding of the biology of this process for identification of potential EMT-targeted therapeutic strategies for the benefit cancer patients is necessary. This review describes recent evidence of EMT involvement in drug resistance and metastasis of cancers, with an emphasis on lung cancer.

Original languageEnglish
Pages (from-to)151-156
Number of pages6
JournalCancer Research and Treatment
Volume44
Issue number3
DOIs
Publication statusPublished - 2012

Keywords

  • Drug resistance
  • Epithelial-mesenchymal transition
  • Lung neoplasms
  • Neoplasm metastasis

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