TY - JOUR
T1 - Epidemiological analysis of risk factors for breast cancer in Indonesian females
AU - Budiningsih, Setyawati
AU - Ohno, Yoshiyuki
AU - Prihartono, Joedo
AU - Ramli, Muchlis
AU - Wakai, Kenji
AU - Cornain, Santoso
AU - Darwis, Idral
AU - Suzuki, Sadao
AU - Tjindarbumi, Didid
AU - Watanabe, Susumu
AU - Tjahjadi, Gunawan
AU - Sakamoto, Goi
AU - Soetrisn, Esti
AU - Roostini, Endang Sri
N1 - Publisher Copyright:
© 1995, Faculty of Medicine, Universitas Indonesia. All rights reserved.
PY - 1995/7/1
Y1 - 1995/7/1
N2 - To identify risk factors in breast cancer development a 3-year epidemiological study was carried out in the joint research project between Indonesia and Japan. Case-control method has been chosen and patients visiting Dr. Cipto Mangunnkusumo National General Hospital, Jakarta were used. Three hundred cases, newly diagnosed primary breast cancer patients, confirmed with histopathological examination were matched by age (+/- 3 years) and socio-economic status with 600 controls. Data collected were demographics, reproductives, breast trauma, radiation exposure, genetical traits,dietary pattern and other lifestyles. The epidemiological data were analyzed by univariate method. The results showed that several factors increased breast cancer risk, namely breast trauma, underweight, naturally occuring menopause, induced menopause, infrequent (1-2 times) pregnancy, short period (less than 4 months) breast feeding, close genetic trait with breast cancer patient and fatty food consumption. Factors reducing the risk of breast cancer were separated marital status, widowed, overweight and irregular menstrual cycle It was concluded that the most prominent risk factors were 1) induced menopause and 2) short period (less than 4 months) breast feeding (Relative Risk of 5.96 and 5.44 respectively). The risk of breast cancer was twice to thrice in patients with underweight, among close genetic traits and those consuming fatty food (Relative Risk of 2.2, 2.85 and 2.63 respectively). Since fatty food consumption was found as one of the significant risk factors, the study has been extended with further nutritional analysis.
AB - To identify risk factors in breast cancer development a 3-year epidemiological study was carried out in the joint research project between Indonesia and Japan. Case-control method has been chosen and patients visiting Dr. Cipto Mangunnkusumo National General Hospital, Jakarta were used. Three hundred cases, newly diagnosed primary breast cancer patients, confirmed with histopathological examination were matched by age (+/- 3 years) and socio-economic status with 600 controls. Data collected were demographics, reproductives, breast trauma, radiation exposure, genetical traits,dietary pattern and other lifestyles. The epidemiological data were analyzed by univariate method. The results showed that several factors increased breast cancer risk, namely breast trauma, underweight, naturally occuring menopause, induced menopause, infrequent (1-2 times) pregnancy, short period (less than 4 months) breast feeding, close genetic trait with breast cancer patient and fatty food consumption. Factors reducing the risk of breast cancer were separated marital status, widowed, overweight and irregular menstrual cycle It was concluded that the most prominent risk factors were 1) induced menopause and 2) short period (less than 4 months) breast feeding (Relative Risk of 5.96 and 5.44 respectively). The risk of breast cancer was twice to thrice in patients with underweight, among close genetic traits and those consuming fatty food (Relative Risk of 2.2, 2.85 and 2.63 respectively). Since fatty food consumption was found as one of the significant risk factors, the study has been extended with further nutritional analysis.
KW - Breast cancer
KW - Case-control study
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=85008613414&partnerID=8YFLogxK
U2 - 10.13181/mji.v4i3.913
DO - 10.13181/mji.v4i3.913
M3 - Article
AN - SCOPUS:85008613414
VL - 4
SP - 163
EP - 168
JO - Medical Journal of Indonesia
JF - Medical Journal of Indonesia
SN - 0853-1773
IS - 3
ER -