Enhancing the sensitivity of dopamine biosensor using PEDOT-PSS modified glassy carbon electrode

Gilar Wisnu Hardi, Siti Fauziyah Rahman

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Citation (Scopus)

Abstract

Abnormal concentrations of dopamine in extracellular fluid are associated with a variety of diseases, such as Parkinson's disease. It, therefore, plays a critical role in the quantitative analysis of dopamine in body fluids in the control of biological drugs as well as in the clinical diagnostic field. Poly (3,4-ethylenedioxythiophene)-(Poly(4-styrenesulfonate)) was successfully fabricated on the surface of the glassy carbon electrode by electrochemical method and used to determine dopamine. The oxidation peaks of dopamine had higher sensitivity at PEDOT-PSS modified electrode in phosphate buffer solution (PBS, pH 6.0). The electrocatalytic activity of the corresponding dopamine electrodes was investigated using cyclic voltammetry (CV) and indicated that PEDOT: PSS by electropolymerization modified had a much higher electrocatalytic oxidation activity for dopamine than any other method. The results obtained have shown that PEDOT: PSS is a promising candidate for the modification of electrode material used in electrochemical sensing and other electrocatalytic applications.

Original languageEnglish
Title of host publication5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
Subtitle of host publicationProceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020
EditorsKenny Lischer, Sugeng Supriadi, Siti Fauziyah Rahman, Yudan Whulanza
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735440869
DOIs
Publication statusPublished - 23 Mar 2021
Event5th International Symposium of Biomedical Engineering, ISBE 2020 - Depok, Virtual, Indonesia
Duration: 28 Jul 202029 Jul 2020

Publication series

NameAIP Conference Proceedings
Volume2344
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference5th International Symposium of Biomedical Engineering, ISBE 2020
Country/TerritoryIndonesia
CityDepok, Virtual
Period28/07/2029/07/20

Keywords

  • Biosensor
  • Dopamine
  • Electrochemical
  • Electropolymerization
  • Glassy carbon electrode
  • PEDOT
  • PSS

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