Enhancing the sensitivity of dopamine biosensor using PEDOT-PSS modified glassy carbon electrode

Gilar Wisnu Hardi; Siti Fauziyah Rahman

doi:10.1063/5.0047170

Enhancing the sensitivity of dopamine biosensor using PEDOT-PSS modified glassy carbon electrode

Gilar Wisnu Hardi, Siti Fauziyah Rahman

Department of Electrical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Citations (Scopus)

Abstract

Abnormal concentrations of dopamine in extracellular fluid are associated with a variety of diseases, such as Parkinson's disease. It, therefore, plays a critical role in the quantitative analysis of dopamine in body fluids in the control of biological drugs as well as in the clinical diagnostic field. Poly (3,4-ethylenedioxythiophene)-(Poly(4-styrenesulfonate)) was successfully fabricated on the surface of the glassy carbon electrode by electrochemical method and used to determine dopamine. The oxidation peaks of dopamine had higher sensitivity at PEDOT-PSS modified electrode in phosphate buffer solution (PBS, pH 6.0). The electrocatalytic activity of the corresponding dopamine electrodes was investigated using cyclic voltammetry (CV) and indicated that PEDOT: PSS by electropolymerization modified had a much higher electrocatalytic oxidation activity for dopamine than any other method. The results obtained have shown that PEDOT: PSS is a promising candidate for the modification of electrode material used in electrochemical sensing and other electrocatalytic applications.

Original language	English
Title of host publication	5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
Subtitle of host publication	Proceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020
Editors	Kenny Lischer, Sugeng Supriadi, Siti Fauziyah Rahman, Yudan Whulanza
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735440869
DOIs	https://doi.org/10.1063/5.0047170
Publication status	Published - 23 Mar 2021
Event	5th International Symposium of Biomedical Engineering, ISBE 2020 - Depok, Virtual, Indonesia Duration: 28 Jul 2020 → 29 Jul 2020

Publication series

Name	AIP Conference Proceedings
Volume	2344
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	5th International Symposium of Biomedical Engineering, ISBE 2020
Country/Territory	Indonesia
City	Depok, Virtual
Period	28/07/20 → 29/07/20

Keywords

Biosensor
Dopamine
Electrochemical
Electropolymerization
Glassy carbon electrode
PEDOT
PSS

Access to Document

10.1063/5.0047170

Cite this

Hardi, G. W., & Rahman, S. F. (2021). Enhancing the sensitivity of dopamine biosensor using PEDOT-PSS modified glassy carbon electrode. In K. Lischer, S. Supriadi, S. F. Rahman, & Y. Whulanza (Eds.), 5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020 [020003] (AIP Conference Proceedings; Vol. 2344). American Institute of Physics Inc.. https://doi.org/10.1063/5.0047170

Hardi, Gilar Wisnu ; Rahman, Siti Fauziyah. / Enhancing the sensitivity of dopamine biosensor using PEDOT-PSS modified glassy carbon electrode. 5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020. editor / Kenny Lischer ; Sugeng Supriadi ; Siti Fauziyah Rahman ; Yudan Whulanza. American Institute of Physics Inc., 2021. (AIP Conference Proceedings).

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title = "Enhancing the sensitivity of dopamine biosensor using PEDOT-PSS modified glassy carbon electrode",

abstract = "Abnormal concentrations of dopamine in extracellular fluid are associated with a variety of diseases, such as Parkinson's disease. It, therefore, plays a critical role in the quantitative analysis of dopamine in body fluids in the control of biological drugs as well as in the clinical diagnostic field. Poly (3,4-ethylenedioxythiophene)-(Poly(4-styrenesulfonate)) was successfully fabricated on the surface of the glassy carbon electrode by electrochemical method and used to determine dopamine. The oxidation peaks of dopamine had higher sensitivity at PEDOT-PSS modified electrode in phosphate buffer solution (PBS, pH 6.0). The electrocatalytic activity of the corresponding dopamine electrodes was investigated using cyclic voltammetry (CV) and indicated that PEDOT: PSS by electropolymerization modified had a much higher electrocatalytic oxidation activity for dopamine than any other method. The results obtained have shown that PEDOT: PSS is a promising candidate for the modification of electrode material used in electrochemical sensing and other electrocatalytic applications.",

keywords = "Biosensor, Dopamine, Electrochemical, Electropolymerization, Glassy carbon electrode, PEDOT, PSS",

author = "Hardi, {Gilar Wisnu} and Rahman, {Siti Fauziyah}",

note = "Funding Information: We gratefully acknowledge the funding from Universitas Indonesia through Publikasi Terindeks Internasional (PUTI) Saintekes 2020 No. NKB-2450/UN2RST/HKP.05.00/2020. We also express our gratitude to Dr.Eng. Arief Udhiarto, S.T., M.T., Head of Laboratory nanodevice, MRPQ building for allowing to use the laboratory facilities during this research. Publisher Copyright: {\textcopyright} 2021 Author(s).; 5th International Symposium of Biomedical Engineering, ISBE 2020 ; Conference date: 28-07-2020 Through 29-07-2020",

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doi = "10.1063/5.0047170",

language = "English",

series = "AIP Conference Proceedings",

publisher = "American Institute of Physics Inc.",

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Hardi, GW & Rahman, SF 2021, Enhancing the sensitivity of dopamine biosensor using PEDOT-PSS modified glassy carbon electrode. in K Lischer, S Supriadi, SF Rahman & Y Whulanza (eds), 5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020., 020003, AIP Conference Proceedings, vol. 2344, American Institute of Physics Inc., 5th International Symposium of Biomedical Engineering, ISBE 2020, Depok, Virtual, Indonesia, 28/07/20. https://doi.org/10.1063/5.0047170

Enhancing the sensitivity of dopamine biosensor using PEDOT-PSS modified glassy carbon electrode. / Hardi, Gilar Wisnu; Rahman, Siti Fauziyah.
5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020. ed. / Kenny Lischer; Sugeng Supriadi; Siti Fauziyah Rahman; Yudan Whulanza. American Institute of Physics Inc., 2021. 020003 (AIP Conference Proceedings; Vol. 2344).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Enhancing the sensitivity of dopamine biosensor using PEDOT-PSS modified glassy carbon electrode

AU - Hardi, Gilar Wisnu

AU - Rahman, Siti Fauziyah

N1 - Funding Information: We gratefully acknowledge the funding from Universitas Indonesia through Publikasi Terindeks Internasional (PUTI) Saintekes 2020 No. NKB-2450/UN2RST/HKP.05.00/2020. We also express our gratitude to Dr.Eng. Arief Udhiarto, S.T., M.T., Head of Laboratory nanodevice, MRPQ building for allowing to use the laboratory facilities during this research. Publisher Copyright: © 2021 Author(s).

PY - 2021/3/23

Y1 - 2021/3/23

N2 - Abnormal concentrations of dopamine in extracellular fluid are associated with a variety of diseases, such as Parkinson's disease. It, therefore, plays a critical role in the quantitative analysis of dopamine in body fluids in the control of biological drugs as well as in the clinical diagnostic field. Poly (3,4-ethylenedioxythiophene)-(Poly(4-styrenesulfonate)) was successfully fabricated on the surface of the glassy carbon electrode by electrochemical method and used to determine dopamine. The oxidation peaks of dopamine had higher sensitivity at PEDOT-PSS modified electrode in phosphate buffer solution (PBS, pH 6.0). The electrocatalytic activity of the corresponding dopamine electrodes was investigated using cyclic voltammetry (CV) and indicated that PEDOT: PSS by electropolymerization modified had a much higher electrocatalytic oxidation activity for dopamine than any other method. The results obtained have shown that PEDOT: PSS is a promising candidate for the modification of electrode material used in electrochemical sensing and other electrocatalytic applications.

AB - Abnormal concentrations of dopamine in extracellular fluid are associated with a variety of diseases, such as Parkinson's disease. It, therefore, plays a critical role in the quantitative analysis of dopamine in body fluids in the control of biological drugs as well as in the clinical diagnostic field. Poly (3,4-ethylenedioxythiophene)-(Poly(4-styrenesulfonate)) was successfully fabricated on the surface of the glassy carbon electrode by electrochemical method and used to determine dopamine. The oxidation peaks of dopamine had higher sensitivity at PEDOT-PSS modified electrode in phosphate buffer solution (PBS, pH 6.0). The electrocatalytic activity of the corresponding dopamine electrodes was investigated using cyclic voltammetry (CV) and indicated that PEDOT: PSS by electropolymerization modified had a much higher electrocatalytic oxidation activity for dopamine than any other method. The results obtained have shown that PEDOT: PSS is a promising candidate for the modification of electrode material used in electrochemical sensing and other electrocatalytic applications.

KW - Biosensor

KW - Dopamine

KW - Electrochemical

KW - Electropolymerization

KW - Glassy carbon electrode

KW - PEDOT

KW - PSS

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U2 - 10.1063/5.0047170

DO - 10.1063/5.0047170

M3 - Conference contribution

AN - SCOPUS:85103504100

T3 - AIP Conference Proceedings

BT - 5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices

A2 - Lischer, Kenny

A2 - Supriadi, Sugeng

A2 - Rahman, Siti Fauziyah

A2 - Whulanza, Yudan

PB - American Institute of Physics Inc.

T2 - 5th International Symposium of Biomedical Engineering, ISBE 2020

Y2 - 28 July 2020 through 29 July 2020

ER -

Hardi GW, Rahman SF. Enhancing the sensitivity of dopamine biosensor using PEDOT-PSS modified glassy carbon electrode. In Lischer K, Supriadi S, Rahman SF, Whulanza Y, editors, 5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020. American Institute of Physics Inc. 2021. 020003. (AIP Conference Proceedings). doi: 10.1063/5.0047170

Enhancing the sensitivity of dopamine biosensor using PEDOT-PSS modified glassy carbon electrode

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