Encephalomyelitis associated with coronavirus disease 2019: a case report

Riwanti Estiasari, Kartika Maharani, Fitri Octaviana, Anyelir Nielya Mutiara Putri, Syifa Laila Ramadhan, Anna Rozaliani, Darma Imran

Research output: Contribution to journalArticlepeer-review


Background: Despite a considerable number of articles regarding neurological manifestations associated with severe acute respiratory syndrome coronavirus 2 infection, reports on transverse myelitis and encephalitis are scarce. Case presentation: We report a 35-year-old Asian Arab female presenting with longitudinally extensive transverse myelitis within 3 weeks after being diagnosed with mild coronavirus disease 2019 infection. Administration of high-dose methylprednisolone led to significant clinical improvement. However, 2 days after discharge, the patient was readmitted with encephalitis manifestations, consisting of fever and loss of consciousness, along with deterioration in myelitis symptoms. Severe acute respiratory syndrome coronavirus 2 antibody was detected in cerebrospinal fluid, but DNA of severe acute respiratory syndrome coronavirus 2 was not found. Clinical recovery was achieved after the administration of intravenous immunoglobulin. Conclusion: Longitudinally extensive transverse myelitis can be a neurological manifestation of coronavirus disease 2019 and can be followed by encephalomyelitis episodes. High-dose steroids and intravenous immunoglobulin as an immunomodulator are possible effective treatment options.

Original languageEnglish
Article number329
JournalJournal of Medical Case Reports
Issue number1
Publication statusPublished - Dec 2022


  • Case report
  • COVID-19
  • Encephalomyelitis
  • Longitudinally extensive transverse myelitis


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