Encapsulation of oleoresin from ginger (Zingiber officinale var. Roscoe) in vegetable oils based nanoemulsions: Preparation and characterization for oral delivery formulation

Kamarza Mulia, Muhammad Fahmi Zaenal, Elsa Anisa Krisanti

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Nanoemulsion of oleoresin of ginger extract (Zingiber officinale var. Roscoe) in vegetable oil was developed and characterized for the purpose to encapsulate bioactive in ginger for oral delivery formulation. Ginger extract oleoresin was known as natural antitumor, antimicrobial agents and antioxidants, but it has limited therapeutic utilization because of its poor bioavailability and natural physicochemical characteristics. The low solubility of phenolic compounds of oleoresin in the gastrointestinal tract has also been known, as well as its heat sensitivity. In this research nanoemulsions were prepared by using virgin coconut oil (VCO) and palm oil (PO) as the oil phase with various concentrations of Tween 80 surfactant, i.e. 2%, 3% and 4% (w/w). Maceration of fresh and dry ginger in ethanol resulted in oleoresin yield around 9.8mg/g dry ginger. High shear emulsification method formed droplet size of 222nm and 292nm with VCO and PO oil phase, respectively. The highest encapsulation efficiency was obtained in VCO nanoemulsion using 4% Tween 80 surfactant. The accelerated stability testing using centrifugation showed no phase separation in all emulsion samples, thus emulsions have a shelf life of at least one year. The results indicate that VCO and PO nanoemulsion has the potential to be used as an oral delivery formulation of ginger extract oleoresin.

Original languageEnglish
Title of host publication3rd Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
Subtitle of host publicationProceedings of the International Symposium of Biomedical Engineering, ISBE 2018
EditorsPraswasti P.D.K. Wulan, Misri Gozan, Sotya Astutiningsih, Ghiska Ramahdita, Radon Dhelika, Prasetyanugraheni Kreshanti
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735418226
DOIs
Publication statusPublished - 9 Apr 2019
Event3rd International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2018 - Jakarta, Indonesia
Duration: 6 Aug 20188 Aug 2018

Publication series

NameAIP Conference Proceedings
Volume2092
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference3rd International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2018
Country/TerritoryIndonesia
CityJakarta
Period6/08/188/08/18

Keywords

  • ginger-oleoresin
  • nanoemulsion
  • palm-oil
  • vegetable-oil
  • virgin-coconut-oil

Fingerprint

Dive into the research topics of 'Encapsulation of oleoresin from ginger (Zingiber officinale var. Roscoe) in vegetable oils based nanoemulsions: Preparation and characterization for oral delivery formulation'. Together they form a unique fingerprint.

Cite this