Encapsulation of mangosteen extract in virgin coconut oil based nanoemulsions: Preparation and characterization for topical formulation

Kamarza Mulia, Gitasha Afiyah Putri, Elsa Anisa Krisanti

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

5 Citations (Scopus)

Abstract

Nanoemulsions containing extract of mangosteen (Garcinia mangostana L.) rind has been developed and characterized as a topical formulation. The encapsulation of mangosteen extract in nanoemulsions is considered a promising strategy to utilize the available bioactive compounds, particularly α-mangostin. In this study, a high-speed homogenization method was used to produce nanoemulsions of virgin coconut oil as the oil phase, combined Tween 80 and Span 80 as the oil-in-water surfactant, and distilled water as the aqueous phase. The homogenizer speed, oil and surfactant composition, and, hydrophilic lipophilic balance values of the surfactants were varied in order to get the stable nanoemulsions formulation. The most stable nanoemulsion was obtained using a homogenizer speed of 8000 rpm, oil to surfactant volume ratio of 1:1.4, and surfactant hydrophilic lipophilic balance value of 12. Nanoemulsion formulation with average droplet size of 181 nm, zeta potential of-30.9 mV, and 0.01% α-mangostin loading was stable for 28 days without phase separation. Based on the accelerated stability test, the nanoemulsion shelf life is estimated to reach one year. The present study revealed that the virgin coconut oil-based nanoemulsion is a promising carrier of mangosteen extract for topical formulation.

Original languageEnglish
Title of host publicationAdvanced Materials Research - QiR 15
EditorsArdiyansyah Yatim
PublisherTrans Tech Publications Ltd
Pages234-242
Number of pages9
ISBN (Print)9783035712667
DOIs
Publication statusPublished - 1 Jan 2018
Event15th International Conference on Quality in Research, QiR 2017 - Nusa Dua, Bali, Indonesia
Duration: 24 Jul 201727 Jul 2017

Publication series

NameMaterials Science Forum
Volume929 MSF
ISSN (Print)0255-5476

Conference

Conference15th International Conference on Quality in Research, QiR 2017
Country/TerritoryIndonesia
CityNusa Dua, Bali
Period24/07/1727/07/17

Keywords

  • Mangosteen
  • Nanoemulsion
  • Virgin coconut oil
  • α-mangostin

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