@inproceedings{3b104e0fde66496faaa55c6929c4da48,
title = "Encapsulation efficiency and in vitro dissolution test of captopril microcapsule from polyblend poly(D-lactic acid) and polycaprolactone",
abstract = "In this study, captopril drug delivery was made from microcapsules prepared from poly(D-lactic acid) and polycaprolactone using Tween 80-Span 80 surfactant mixture through solvent evaporation method. Based on the optimization result, the optimum mixture of surfactant concentration was found at a concentration of 0.0741 M, resulting in a percent encapsulation efficiency of 28.245 % with a microcapsule size of 0.482 μm. After obtaining the optimum surfactant concentration, an optimization of the ratio of polyblend composition (PDLA: PCL) was carried out. The composition of 2:8 (% w/w) is an optimum composition to produce the best percent encapsulation of 24.0983 %. Dissolution test was conducted on each composition, resulting the best release at composition ratio of 4:6 (% w/w) with 100 % release percentage. The results of FTIR characterization shows that the interactions that occur between PDLA and PCL, and polymers with drugs are physical interactions.",
keywords = "Captopril, microcapsules, mixed surfactants, poly(D-lactic acid), poly(ϵ-caprolactone)",
author = "E. Budianto and I. Fachrudin",
note = "Publisher Copyright: {\textcopyright} 2020 Author(s).; 5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019 ; Conference date: 09-07-2019 Through 10-07-2019",
year = "2020",
month = jun,
day = "1",
doi = "10.1063/5.0008048",
language = "English",
series = "AIP Conference Proceedings",
publisher = "American Institute of Physics Inc.",
editor = "Terry Mart and Djoko Triyono and Ivandini, {Tribidasari Anggraningrum}",
booktitle = "Proceedings of the 5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019",
address = "United States",
}