In this study, captopril drug delivery was made from microcapsules prepared from poly(D-lactic acid) and polycaprolactone using Tween 80-Span 80 surfactant mixture through solvent evaporation method. Based on the optimization result, the optimum mixture of surfactant concentration was found at a concentration of 0.0741 M, resulting in a percent encapsulation efficiency of 28.245 % with a microcapsule size of 0.482 μm. After obtaining the optimum surfactant concentration, an optimization of the ratio of polyblend composition (PDLA: PCL) was carried out. The composition of 2:8 (% w/w) is an optimum composition to produce the best percent encapsulation of 24.0983 %. Dissolution test was conducted on each composition, resulting the best release at composition ratio of 4:6 (% w/w) with 100 % release percentage. The results of FTIR characterization shows that the interactions that occur between PDLA and PCL, and polymers with drugs are physical interactions.