Encapsulation and dissolution study of bromelain in chitosan-methyl cellulose semi-IPN hydrogel

Muhammad Adi Putranto, Emil Budianto, Sumi Hudoyon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Bromelain is a proteolytic enzyme which has functions for anti-inflammatory, antiplatelet, anticancer, and as a drug for digestion problem. To achieve its function for drug digestion problem, bromelain is encapsulated in Chitosan-Methyl Cellulose semi-IPN hydrogel. There are three research questions for this research is it the encapsulation of bromelain in Hydrogel Chitosan-methyl Cellulose occur 100% complete? Is it the release complete in pH 7.4 as artificial intestine? Is it bromelain which is released in artificial intestine still have their activity as an enzyme? The hydrogel was made using the semi-IPN method with Chitosan-Methyl Cellulose 60:40(w/w), glutaraldehyde 0.1 M (2% w/w Chitosan) as a crosslinker, and a bromelain as a drug model. Encapsulation of bromelain was done with post loading and dissolution was done by simply putting encapsulated hydrogel in the shaker for 10 hours. FTIR and Optical Microscope are chosen as a characterization instrument. The result showed encapsulation achieved an average 97% and an average of dissolution 97%. The enzymatic activity bromelain decrease in an average of 57%.

Original languageEnglish
Title of host publication3rd International Seminar on Chemistry
Subtitle of host publicationGreen Chemistry and Its Role for Sustainability
EditorsFredy Kurniawan, Yuly Kusumawati, Sri Fatmawati, Hendro Juwono, Adi Setyo Purnomo
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735417755
DOIs
Publication statusPublished - 14 Dec 2018
Event3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability, ISOC 2018 - Surabaya, Indonesia
Duration: 18 Jul 201819 Jul 2018

Publication series

NameAIP Conference Proceedings
Volume2049
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability, ISOC 2018
CountryIndonesia
CitySurabaya
Period18/07/1819/07/18

Fingerprint Dive into the research topics of 'Encapsulation and dissolution study of bromelain in chitosan-methyl cellulose semi-IPN hydrogel'. Together they form a unique fingerprint.

Cite this