Elevated levels of T cell activation antigen CD27 and increased interleukin‐4 production in human lymphatic filariasis

Maria Yazdanbakhsh, Erliyani Sartono, Yvonne C.M. Kruize, Agnes Kurniawan, Tineke van der Pouw‐Kraan, Peter H. van der Meide, Murray E. Selkirk, Felix Partono, Rogier Q. Hintzen, René A.W. van Lier, Rick M. Maizels

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Abstract

To assess the immunological changes occurring during filarial infection with or without elephantiasis, 145 patients in different clinical groups from an endemic area in Indonesia were compared with respect to plasma levels of both soluble CD25 (sCD25) and sCD27; interleukin‐4 (IL‐4) and interferon‐γ release by peripheral blood mononuclear cells was also measured in a smaller subset of individuals. Levels of sCD27 were significantly elevated in elephantiasis and microfilaremic patients compared with endemic normals (p < 0.002), whereas sCD25 levels remained low in microfilaremics and was only slightly elevated in elephantiasis patients compared with endemic normals (p <0.02). As activated T cell populations release both sCD27 and sCD25, these findings imply that there is filarial‐driven activation of a Tcell subset that releases sCD27 rather than sCD25. The expansion of a particular Tcell population by filarial parasites is further suggested by the enhancement in both IL‐4‐producing and CD4+CD27T cells in PBMC from elephantiasis and microfilaremic patients compared with endemic normals. More detailed characterization and comparison of CD27 lymphocytes from these individuals may identify mechanisms involved in the pathogenesis of lymphatic filariasis.

Original languageEnglish
Pages (from-to)3312-3317
Number of pages6
JournalEuropean Journal of Immunology
Volume23
Issue number12
DOIs
Publication statusPublished - 1 Jan 1993

Keywords

  • Interferon‐γ
  • Interleukin‐4
  • Lymphatic filariasis
  • Soluble CD25
  • Soluble CD27

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    Yazdanbakhsh, M., Sartono, E., Kruize, Y. C. M., Kurniawan, A., van der Pouw‐Kraan, T., van der Meide, P. H., Selkirk, M. E., Partono, F., Hintzen, R. Q., van Lier, R. A. W., & Maizels, R. M. (1993). Elevated levels of T cell activation antigen CD27 and increased interleukin‐4 production in human lymphatic filariasis. European Journal of Immunology, 23(12), 3312-3317. https://doi.org/10.1002/eji.1830231238