Electroacupuncture effect at the LI 4 Hegu point on the plasma β-endorphin level of healthy subjects

A. L. Setiawardhani, A. Srilestari, C. Simadibrata

Research output: Contribution to journalConference articlepeer-review

1 Citation (Scopus)


As a therapy modality, acupuncture is becoming popular for treating diseases. Nevertheless, the acupuncture mechanism of action remains unclear until now. Some studies suggest that acupuncture works by stimulating the β-endorphin release, whereas other studies show the opposite. This study aims to determine whether electro acupuncture at the LI 4 Hegu point could increase the plasma β-endorphin level as a basic of acupuncture mechanism of action. Thirty-six healthy subjects were involved and divided randomly into two groups, namely, intervention (n=18) and control (n=18). In the intervention group, electroacupuncture was applied at the LI 4 Hegu point with a low frequency for 30 min. In the control group, sham electroacupuncture was applied at a non-acupoint for 30 min. The plasma β-endorphin was examined before and after intervention using the ELISA method. A significant difference was found between the intervention and control groups in increasing the plasma β-endorphin level (9(50%) vs. 1(5.6%); p = 0.009). A significant difference was also observed in the plasma β-endorphin level after intervention between the two groups (35.1±3.4 vs. 10.3±1.8; p=0.003). Electroacupuncture at the LI 4 Hegu point was found to increase the plasma β-endorphin level in healthy subjects.

Original languageEnglish
Article number012027
JournalJournal of Physics: Conference Series
Issue number1
Publication statusPublished - 30 Aug 2017
Event1st Physics and Technologies in Medicine and Dentistry Symposium, PTMDS 2017 - Depok, West Java, Indonesia
Duration: 15 Jul 201716 Jul 2017


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