TY - JOUR
T1 - Elabela
T2 - novel perspectives on vascular physiology and disease
AU - Hendrianus,
AU - Adiarto, Suko
AU - Prakoso, Radityo
N1 - Funding Information:
The authors gratefully acknowledge Prof. Frans Ferdinal, MD, PhD at the Department of Biochemistry and Molecular Biology, Faculty of Medicine Tarumanagara University, Jakarta, Indonesia, for sharing his pearls of knowledge about the apelinergic system, which includes the apelin receptor (APJ) and its two specific ligands, apelin and elabela.
Publisher Copyright:
Copyright © 2022 Via Medica.
PY - 2022
Y1 - 2022
N2 - Recently, a novel endogenous ligand of APJ called elabela has been identified to play an important role in cardiovascular development. Elabela and its G-protein-coupled receptor APJ are widely expressed throughout the human body. These have been identified to play a significant role in diverse biological processes, especially in the normal and pathological cardiovascular systems. In addition, increasing evidence indicates that elabela is also intimately associated with a large number of vascular physiological processes in adulthood, such as angiogenesis, vascular tone and atherosclerosis. However, a comprehensive summary of elabela in the vascular system has not been reported to date. In this review, we provide an overview of elabela in vascular physiology and diseases. Collectively, elabela, a potential biomarker and therapeutic peptide, exerts diverse biological vascular effects in adults.
AB - Recently, a novel endogenous ligand of APJ called elabela has been identified to play an important role in cardiovascular development. Elabela and its G-protein-coupled receptor APJ are widely expressed throughout the human body. These have been identified to play a significant role in diverse biological processes, especially in the normal and pathological cardiovascular systems. In addition, increasing evidence indicates that elabela is also intimately associated with a large number of vascular physiological processes in adulthood, such as angiogenesis, vascular tone and atherosclerosis. However, a comprehensive summary of elabela in the vascular system has not been reported to date. In this review, we provide an overview of elabela in vascular physiology and diseases. Collectively, elabela, a potential biomarker and therapeutic peptide, exerts diverse biological vascular effects in adults.
KW - apelin
KW - APJ
KW - elabela
KW - vascular system
UR - http://www.scopus.com/inward/record.url?scp=85147956747&partnerID=8YFLogxK
U2 - 10.5603/AH.a2022.0016
DO - 10.5603/AH.a2022.0016
M3 - Review article
AN - SCOPUS:85147956747
SN - 2449-6170
VL - 26
SP - 135
EP - 140
JO - Arterial Hypertension (Poland)
JF - Arterial Hypertension (Poland)
IS - 3
ER -
