Ekspresi Imunositokimia Hector Battifora Mesothelioma Cell-1 (HBME-1) pada Nodul Tiroid Diferensiasi Sel Folikel

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Abstract

Background Fine needle aspiration biopsy (FNAB) of thyroid nodules is necessary for preoperative screening because the accurate cytologic diagnosis used as a reference clinician in patient management. There is a picture of the intermediate cytomorphologic which is difficult within determine wethere the lesion is benign or malignant, so it needs immunocytochemistry to improve the accuracy. HBME-1 has been widely used in tissue specimens as a marker of thyroid carcinoma with high sensitivity and specificity. The aim of this study is to determine the diagnostic value of HBME-1 in thyroid FNAB specimens. Methods The descriptive analytic observasional study with a cross-sectional was conducted 54 cytologic specimens of thyroid nodule by consecutive manner. Sample were collected from 2010-2012 according of Bethesda classification 2007. All samples were subjected to HBME-1 stain. The assessment of sensitivity and specificity used histology diagnostic as the gold standard. Statistical test assessed by Fisher’s excact test using SPSS 20. Results Forty three out of 45 (96%) cases of thyroid carcinoma follicular differentiation showed positive HBME-1 and only 1 of 9 (11%) cases of benign lessions was positive. There was a significant association between HBME-1 positivity with thyroid carcinoma follicular differentiation (p<0.001). Conclusion HBME-1 staining could distinguish benign and malignant thyroid follicular cell differentiation lesions in FNAB specimens with sensitivity values of 93% and specificity of 89%. Positive predictive value was 98%, the negative predictive value was 73% and diagnostic accuracy was 93%. Key words: follicular differentiation, HBME-1, immunocytochemistry, thyroid nodules.
Original languageEnglish
JournalMajalah Patologi Indonesia
Publication statusPublished - 2015

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