Ibuprofen is an analgesic anti-inflammatory nonsteroidal (AINS). Generally, ibuprofenhave a bad flowability because a high cohesivity. Another problem in manufacturingis the high tendency for sticking to the punches. Besides these disadvantageous properties,ibuprofen indicates bad dissolution behavior because of its hydrophobic structure.To improve the properties of ibuprofen can be used crystallization method withusing variation of solvents. In this experiment observed crystallization method bycooling, evaporation, and water presence, which used methanol, ethanol, and acetonesolvents. Of all the crystallization results are produced white prism-shaped crystalline.The selected method is cooling method, which is characterized using ScanningElectron Microscopy (SEM), powder X-ray diffraction, and Differential ScanningCalorimetry (DSC). These three characterizations indicate transformation of crystalform which compared with ibuprofen’s standard. The selected method also producesnon cohesive powder which have the size particle is 710-1180µm, compressibilityindex: IBMD 14.2%, IBED 16.6%, IBAD 17.1%; angles of repose: IBMD 28.1º,IBED 29.7º, IBAD 30.1º, and have higher solubility than the common crystal’ssolubility. The result indicates that crystallization method is able to improve flowrate,compressibility index, and dissolution rate properties of ibuprofen’s standard.
|Journal||Pharmaceutical Sciences and Research (PSR)|
|Publication status||Published - 2010|