Efficacy of mouth rinse formulation based on cetyl pyridinium chloride in the control of plaque as an early onset of dental calculus built up

This study aimed at comparing the antiplaque and antigingivitis potential of a mouth rinse containing Essential Oil, zinc and fluoride with a CPC-containing mouth rinse over a short term period. This study is a double blind randomized cross over clinical trial with a 3 days run in phase (wash out period). A non-brushing 3 days intervention was conducted with 18 females with mean age of 21 years old and a single examiner throughout the study. Prophylaxis was done after each intervention. Four mouth rinse were tested on 4 groups; 1: negative control, 2: mouthwash with alcohol, 3: mouthwash with CPC 0.1%, and 4: mouthwash with CPC 0.07%. Oral hygiene scores which consist of Plaque Index (PI), Gingival Index (GI), and bacterial load measurement using CariScreen were taken and analyzed. The result shows that the most effective to the less effective mouth rinse in inhibiting bacterial built up (antiplaque) are mouthwash 2, 3, 4 and 1 respectively. However, but with no statistically significant effect in antigingivitis.