Efficacy of lotion containing fractions of Selaginella Plana leaves and Lagenaria Siceraria (molina) standl. Fruit for relief of skin erythema

Objective: The aim of this study is to evaluate the physical stability of two lotion formulations containing Selaginella plana and Lagenaria siceraria (Molina) Standl. and investigated their safety and efficacy to relieve erythema due to exposure to the sun. Methods: We conducted a randomized controlled trial consisting of five treatment groups: Negative control, positive control, neutral control, formula A test group (containing a 1% ethanolic fraction of S. plana and a 0.5% ethanolic fraction of L. siceraria [Molina] Standl.), and formula B test group (containing a 0.5% ethanolic fraction of S. plana and a 1% ethanolic fraction of L. siceraria [Molina] Standl.). Each group had erythema induced by exposure to sunlight for 30 min between 10:00 and 16:00. The severities of erythema 1, 3, and 24 h after application were assessed. Results: Formula A was significantly better than formula B (p<0.05) at reducing the severity of erythema. Conclusion: Formula A containing a 1% ethanol fraction of S. plana and a 0.5% ethanol fraction of L. siceraria (Molina) Standl. showed the greatest reduction in the level of erythema (p<0.05). S. plana may reduce the prostaglandin synthesis caused by sun exposure.