Efficacy and safety of catheter ablation for atrial fibrillation in congenital heart disease – A systematic review and meta-analysis

Raymond Pranata, Alexander Edo Tondas, Emir Yonas, Veresa Chintya, Muhammad Yamin

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Background: Prevalence of atrial fibrillation (AF) in patients with congenital heart disease (CHD) is on the rise. Anti-arrhythmic drugs are usually the first line of treatment in CHD, however, it is often ineffective and poorly tolerated. We aimed to perform a systematic review to assess the efficacy and safety of catheter ablation for AF in CHD. Methods: We performed a comprehensive search on catheter ablation for atrial fibrillation in congenital heart disease up until July 2019 through several electronic databases. Results: Ablation of AF in patients with CHD had a modest 12 months AF freedom ranging from 32.8% to 63%, which can be increased by subsequent/repeat ablation. The complexity of CHD appears to have a significant effect on a study but not in others. Catheter ablation in ASD and persistent left superior vena cava had a high success rate. Overall, catheter ablation is safe whichever the type of CHD is. Conclusion: Catheter ablation for AF in CHD had modest efficacy that can be increased by subsequent/repeat ablation and it also has an excellent safety profile. Ablation in complex CHD could also have similar efficacy, however, it is preferably done by experts in a high volume tertiary center.

Original languageEnglish
Pages (from-to)216-221
Number of pages6
JournalIndian Pacing and Electrophysiology Journal
Volume19
Issue number6
DOIs
Publication statusAccepted/In press - 1 Jan 2019

Keywords

  • Atrial fibrillation
  • Catheter ablation
  • Congenital heart disease
  • Efficacy
  • Safety

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