TY - JOUR
T1 - Effects of realimentation on small intestinal morphology and disaccharidase activity in malnutrition Sprague-Dawley rats
AU - Sosrosumihardjo, Rustadi
AU - Firmansyah, Agus
AU - Rasad, Asri
AU - Harjodisastro, Daldiyono
AU - Ridwan, Endi
AU - Wanandi, Septelia Inawati
AU - Gunarti, Dwirini Retno
N1 - Publisher Copyright:
© 2006 Faculty of Medicine, Universitas Indonesia. All rights reserved.
PY - 2006/10/1
Y1 - 2006/10/1
N2 - Low birth-weight infant and intrauterine growth retardation are still a health problem, especially in Indonesia due to high prevalence and need to be reduced. Malnutrition in infants are most common occur in low birth-weight infants. Malnutrition in rats resulted in hypotrophic and normoplastic mucosa of the small intestine. The finding was not only showed that small intestine was able to maintain its cell number in condition with restriction nutrient, however also suggested the posibility of epithelial regeneration if given adequate nutrient intake. Did realimentation recover the hypotrophic normoplastic mucosa to normotrophic normoplastic? The study aim to answer that question. Experimental animal study with post test-control group design was performed using 40 male litter of Sprague-Dawley rats, was fed standard chow. The study was divided into phases prenatally-induced malnutrition and continued with phase realimentation. The result of this study is the body weight, mucosal thickness, villus height, cryptus depth, ratio of villus/crypt, number of villi, protein content, and disaccharidases of rats realimentation group was higher than non-realimentation group, but lower than control group. Prenatally-induced malnutrition did not reduced the population of small intestinal enterocytes. Realimentation in rats in prenatally-induced malnutrition was able to improve the hypotrophy of small intestinal mucosa and to increase the disaccharidases activities but did not reach the normal values. Realimentation in rats in prenatally-induced malnutrition was able to improve the maturity of small intestine mucosa but did not reach the normal values. The information will be helpfull to decide the policy of maternal malnutrition.
AB - Low birth-weight infant and intrauterine growth retardation are still a health problem, especially in Indonesia due to high prevalence and need to be reduced. Malnutrition in infants are most common occur in low birth-weight infants. Malnutrition in rats resulted in hypotrophic and normoplastic mucosa of the small intestine. The finding was not only showed that small intestine was able to maintain its cell number in condition with restriction nutrient, however also suggested the posibility of epithelial regeneration if given adequate nutrient intake. Did realimentation recover the hypotrophic normoplastic mucosa to normotrophic normoplastic? The study aim to answer that question. Experimental animal study with post test-control group design was performed using 40 male litter of Sprague-Dawley rats, was fed standard chow. The study was divided into phases prenatally-induced malnutrition and continued with phase realimentation. The result of this study is the body weight, mucosal thickness, villus height, cryptus depth, ratio of villus/crypt, number of villi, protein content, and disaccharidases of rats realimentation group was higher than non-realimentation group, but lower than control group. Prenatally-induced malnutrition did not reduced the population of small intestinal enterocytes. Realimentation in rats in prenatally-induced malnutrition was able to improve the hypotrophy of small intestinal mucosa and to increase the disaccharidases activities but did not reach the normal values. Realimentation in rats in prenatally-induced malnutrition was able to improve the maturity of small intestine mucosa but did not reach the normal values. The information will be helpfull to decide the policy of maternal malnutrition.
KW - Disaccharidase activity
KW - Prenatally-induced malnutrition
KW - Realimentation
KW - Small intestinal morphology
KW - Sprague-Dawley rats
UR - http://www.scopus.com/inward/record.url?scp=85008675567&partnerID=8YFLogxK
U2 - 10.13181/mji.v15i4.238
DO - 10.13181/mji.v15i4.238
M3 - Article
AN - SCOPUS:85008675567
SN - 0853-1773
VL - 15
SP - 208
EP - 216
JO - Medical Journal of Indonesia
JF - Medical Journal of Indonesia
IS - 4
ER -