@inproceedings{c1e7bebdde5d4aecb68c0d7263e34129,
title = "Effects of pore forming agents of potassium bicarbonate and drug loading method against dissolution mechanisms of amoxicillin drugs encapsulated in hydrogel full-Ipn chitosan-poly(N -vinylcaprolactam) as a floating drug delivery system",
abstract = "The limitation of amoxicillin trihydrate in the treatment of H. pylori bacteria is relatively short retention time in the stomach. The FDDS (Floating Drug Delivery System) amoxicillin trihydrate into a chitosan-poly(N-vinylcaprolactam) full-Ipn hydrogel matrix using a pore-forming agent KHCO3 is expected to overcome these limitations. The pore-forming agent to be used is 15% KHCO3 compound. Chemical kinetics approach is performed to determine the dissolution mechanism of amoxicillin trihydrate from K-PNVCL hydrogel in vitro on gastric pH and characterization using SEM performed to confirm the dissolution mechanism. Hydrogels with the addition of pore-forming agents will be loading in situ loading and post loading. Fourier Transform Infra Red (FTIR) spectroscopy was used to characterize K-PNVCL and UV-Vis hydrogels used to calculate the efficiency of encapsulation and drug dissolution rate in K-PNVCL hydrogel. Hydrogel K-PNVCL / KHCO3 that encapsulated by in situ loading method resulted in an encapsulation efficiency of 93.5% and dissolution of 93.4%. While the Hydrogel K-PNVCL / KHCO3 which is drug encapsulation resulted in an encapsulation efficiency of 87.2% with dissolution of 81.5%. Chemical kinetics approach to in situ encapsulation of loading and post loading shows the dissolution mechanism occurring in the K-PNVCL / KHCO3 hydrogel matrix occurs by diffusion. Observation using optical microscope and SEM showed the mechanism of drug dissolution in Hydrogel K-PNVCL occurred by diffusion.",
keywords = "FDDS, Hydrogel, chemical kinetics, diffusion, dissolution mechanism, poly(N-Vinylcaprolactam), pore forming agent",
author = "Nurul Aini and Rahayu, {Dyah Utami Cahyaning} and Emil Budianto",
note = "Funding Information: The Authors would like to thank Directorate of Research and Community Engagement (DRPM) Universitas Indonesia for supporting our research financially through Hibah Publikasi Internasional Terindeks untuk Tugas Akhir (Hibah PITTA) 2017. We also would like to thank Department of Chemistry, Universitas Indonesia for supporting us and providing the instrumental facilities for our research. Dyah Utami Cahyaning Rahayu and Emil Budianto as supervisor this research and designed the research pipeline, while Nurul Aini conducted the experimental details, analyzed the data, and wrote the final manuscript. Herewith, we would declare that there is no conflict of interest regarding this manuscript. Publisher Copyright: {\textcopyright} 2018 Author(s).; 3rd International Conference on Materials and Metallurgical Engineering and Technology: Advancing Innovation in Materials Science, Technology and Applications for Sustainable Future, ICOMMET 2017 ; Conference date: 30-10-2017 Through 31-10-2017",
year = "2018",
month = apr,
day = "3",
doi = "10.1063/1.5030224",
language = "English",
series = "AIP Conference Proceedings",
publisher = "American Institute of Physics Inc.",
editor = "Hidayat, {Mas Irfan P.}",
booktitle = "Proceedings of the 3rd International Conference on Materials and Metallurgical Engineering and Technology, ICOMMET 2017",
}