Effects of pore forming agents of potassium bicarbonate and drug loading method against dissolution mechanisms of amoxicillin drugs encapsulated in hydrogel full-Ipn chitosan-poly(N -vinylcaprolactam) as a floating drug delivery system

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The limitation of amoxicillin trihydrate in the treatment of H. pylori bacteria is relatively short retention time in the stomach. The FDDS (Floating Drug Delivery System) amoxicillin trihydrate into a chitosan-poly(N-vinylcaprolactam) full-Ipn hydrogel matrix using a pore-forming agent KHCO3 is expected to overcome these limitations. The pore-forming agent to be used is 15% KHCO3 compound. Chemical kinetics approach is performed to determine the dissolution mechanism of amoxicillin trihydrate from K-PNVCL hydrogel in vitro on gastric pH and characterization using SEM performed to confirm the dissolution mechanism. Hydrogels with the addition of pore-forming agents will be loading in situ loading and post loading. Fourier Transform Infra Red (FTIR) spectroscopy was used to characterize K-PNVCL and UV-Vis hydrogels used to calculate the efficiency of encapsulation and drug dissolution rate in K-PNVCL hydrogel. Hydrogel K-PNVCL / KHCO3 that encapsulated by in situ loading method resulted in an encapsulation efficiency of 93.5% and dissolution of 93.4%. While the Hydrogel K-PNVCL / KHCO3 which is drug encapsulation resulted in an encapsulation efficiency of 87.2% with dissolution of 81.5%. Chemical kinetics approach to in situ encapsulation of loading and post loading shows the dissolution mechanism occurring in the K-PNVCL / KHCO3 hydrogel matrix occurs by diffusion. Observation using optical microscope and SEM showed the mechanism of drug dissolution in Hydrogel K-PNVCL occurred by diffusion.

Original languageEnglish
Title of host publicationProceedings of the 3rd International Conference on Materials and Metallurgical Engineering and Technology, ICOMMET 2017
Subtitle of host publicationAdvancing Innovation in Materials Science, Technology and Applications for Sustainable Future
EditorsMas Irfan P. Hidayat
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735416406
DOIs
Publication statusPublished - 3 Apr 2018
Event3rd International Conference on Materials and Metallurgical Engineering and Technology: Advancing Innovation in Materials Science, Technology and Applications for Sustainable Future, ICOMMET 2017 - Surabaya, Indonesia
Duration: 30 Oct 201731 Oct 2017

Publication series

NameAIP Conference Proceedings
Volume1945
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference3rd International Conference on Materials and Metallurgical Engineering and Technology: Advancing Innovation in Materials Science, Technology and Applications for Sustainable Future, ICOMMET 2017
CountryIndonesia
CitySurabaya
Period30/10/1731/10/17

Keywords

  • chemical kinetics
  • diffusion
  • dissolution mechanism
  • FDDS
  • Hydrogel
  • poly(N-Vinylcaprolactam)
  • pore forming agent

Fingerprint Dive into the research topics of 'Effects of pore forming agents of potassium bicarbonate and drug loading method against dissolution mechanisms of amoxicillin drugs encapsulated in hydrogel full-Ipn chitosan-poly(N -vinylcaprolactam) as a floating drug delivery system'. Together they form a unique fingerprint.

Cite this