Effects of pearl grass extract capsules on osteoarthritis subject

Nita Sari Wijaya, Katrin Basah, Anton Bahtiar

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Pearl grass extract, a standardized bioactive polar extract of the herbs of Hedyotis corymbosa, is preclinically proven to have an activity to osteoarthritis and rheumatoid arthritis properties in an animal model.The current clinical study has evaluated the efficacy and safety of Pearl grass extract of osteoarthritis subjects. This research was a pilot study of osteoarthritis subjects using Parallel double-blind study design. Subjects have normal renal and liver function, above 50 years of age, and has a sign and symptoms of osteoarthritis included in the study. In the treatment, Pearl grass capsules were given as one capsule once daily for eight weeks, throughout the study, the weekly assessment to evaluate the adverse event. Thirty subjects of mean age 55.90 ± 3.7 years were evaluable. Pearl grass extract capsules did not change renal and liver function in 56 days treatment. Pearl grass capsule markedly reduced the consumption of analgesic drug compared with placebo groups. Pearl grass capsules also decreased pain scale better compare with placebo.

Original languageEnglish
Pages (from-to)303-310
Number of pages8
JournalPharmacognosy Journal
Issue number2
Publication statusPublished - 1 Jan 2020


  • Clinical efficacy
  • Pearl grass extract capsules
  • Quercetin
  • VAS scale
  • WOMAC scale


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