Effects of odontocem and mineral trioxide aggregate-angelus toxicity on fibroblast viability

Dewi Sri Kesumawati, Anggraini Margono, Endang Suprastiwi

Research output: Contribution to journalArticlepeer-review


Objective: Mineral trioxide aggregate (MTA) is proven to be biocompatible and is used for pulp capping treatment. Odontocem, calcium silicate-based cement similar to MTA with the addition of a steroid, has recently been developed and to compare the effects of Odontocem and MTA-Angelus toxicity on fibroblast cell viability. Methods: Fibroblast cells from embryonated chicken eggs were immersed in Odontocem or MTA-Angelus solution for 24 and 72 h. Cell viability was analyzed by Microculture Tetrazolium (MTT) 3-(4,5-dimethylthiazol-2- yl)2,5-diphenyltetrazolium bromide assay. Results: After 24 h, the Odontocem and MTA-Angelus groups showed significantly lower viability (p<0.05) compared with controls. After 72 h, cell viability was significantly higher in the Odontocem and MTA-Angelus groups. However, there was no significant difference between the Odontocem and MTA-Angelus groups. Conclusions: Odontocem and MTA-Angelus have low toxicity for dental applications.

Original languageEnglish
Pages (from-to)32-34
Number of pages3
JournalInternational Journal of Applied Pharmaceutics
Publication statusPublished - 1 Apr 2019


  • Fibroblast cells
  • Mineral Trioxide Aggregate
  • Odontocem
  • Toxicity


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