[Effects of nanoparticle-rich-diesel exhaust on steroidogenesis in rats and the mechanism underlying such effects].

Nozomi Yamagishi, Yuki Ito, Doni Hikmat Ramdhan, Tamie Nakajima

Research output: Contribution to journalReview articlepeer-review

Abstract

Diesel exhaust (DE) is one of the major air pollutants in the world. DE disrupts steroid hormone levels, which may result from the disruption of spermatogenesis. Steroidogenesis occurs not only in the testis but also in the brain. Therefore, we investigated the effects of nanoparticle-rich DE (NR-DE) on steroidogenesis in both the testis and hippocampus. Exposure to NR-DE at concentrations comparable to the environmental standard for particulate matters 2.5 (PM(2.5)) in Japan increased plasma testosterone level. This exposure increased the expression levels of genes involved in steroidogenesis in the testis, but not in the hippocampus, suggesting that NR-DE disrupts steroid hormone balance. This finding suggests the need to reconsider the environmental limit of PM(2.5) in Japan.

Original languageEnglish
Pages (from-to)634-637
Number of pages4
JournalNihon eiseigaku zasshi. Japanese journal of hygiene
Volume66
Issue number4
DOIs
Publication statusPublished - 1 Jan 2011

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