[Effects of nanoparticle-rich-diesel exhaust on steroidogenesis in rats and the mechanism underlying such effects].

Nozomi Yamagishi; Yuki Ito; Doni Hikmat Ramdhan; Tamie Nakajima

doi:10.1265/jjh.66.634

[Effects of nanoparticle-rich-diesel exhaust on steroidogenesis in rats and the mechanism underlying such effects].

Nozomi Yamagishi, Yuki Ito, Doni Hikmat Ramdhan, Tamie Nakajima

Department of Occupational Health and Safety

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

Diesel exhaust (DE) is one of the major air pollutants in the world. DE disrupts steroid hormone levels, which may result from the disruption of spermatogenesis. Steroidogenesis occurs not only in the testis but also in the brain. Therefore, we investigated the effects of nanoparticle-rich DE (NR-DE) on steroidogenesis in both the testis and hippocampus. Exposure to NR-DE at concentrations comparable to the environmental standard for particulate matters 2.5 (PM(2.5)) in Japan increased plasma testosterone level. This exposure increased the expression levels of genes involved in steroidogenesis in the testis, but not in the hippocampus, suggesting that NR-DE disrupts steroid hormone balance. This finding suggests the need to reconsider the environmental limit of PM(2.5) in Japan.

Original language	English
Pages (from-to)	634-637
Number of pages	4
Journal	Nihon eiseigaku zasshi. Japanese journal of hygiene
Volume	66
Issue number	4
DOIs	https://doi.org/10.1265/jjh.66.634
Publication status	Published - 2011

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abstract = "Diesel exhaust (DE) is one of the major air pollutants in the world. DE disrupts steroid hormone levels, which may result from the disruption of spermatogenesis. Steroidogenesis occurs not only in the testis but also in the brain. Therefore, we investigated the effects of nanoparticle-rich DE (NR-DE) on steroidogenesis in both the testis and hippocampus. Exposure to NR-DE at concentrations comparable to the environmental standard for particulate matters 2.5 (PM(2.5)) in Japan increased plasma testosterone level. This exposure increased the expression levels of genes involved in steroidogenesis in the testis, but not in the hippocampus, suggesting that NR-DE disrupts steroid hormone balance. This finding suggests the need to reconsider the environmental limit of PM(2.5) in Japan.",

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AU - Nakajima, Tamie

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AB - Diesel exhaust (DE) is one of the major air pollutants in the world. DE disrupts steroid hormone levels, which may result from the disruption of spermatogenesis. Steroidogenesis occurs not only in the testis but also in the brain. Therefore, we investigated the effects of nanoparticle-rich DE (NR-DE) on steroidogenesis in both the testis and hippocampus. Exposure to NR-DE at concentrations comparable to the environmental standard for particulate matters 2.5 (PM(2.5)) in Japan increased plasma testosterone level. This exposure increased the expression levels of genes involved in steroidogenesis in the testis, but not in the hippocampus, suggesting that NR-DE disrupts steroid hormone balance. This finding suggests the need to reconsider the environmental limit of PM(2.5) in Japan.

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[Effects of nanoparticle-rich-diesel exhaust on steroidogenesis in rats and the mechanism underlying such effects].

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