Effects of nanocurcumin in rats with diabetes induced with streptozotocin and nicotinamide: MRNA expression of B-type natriuretic peptide

Maryam Ulfa, Dyah Suci Handayani, Hotlina Nainggolan, Wawaimuli Arozal

Research output: Contribution to journalArticle

Abstract

Objective: This study aimed to determine the effects of nanocurcumin on cardiomyopathy, assessed by the expression of B-type natriuretic peptide (BNP) mRNA in heart tissue. Methods: Type 2 diabetic rats were induced with streptozotocin and nicotinamide. Nanocurcumin was orally administered (100 mg/kg/day) for 30 days. BNP-45 mRNA expression in the heart tissue was measured using quantitative reverse transcription-polymerase chain reaction and calculated using the Livak method. Results: BNP-45 levels increased significantly (p<0.05) in diabetic rats compared with the normal group. Nanocurcumin treatment at a dose of 100 mg/kg for 30 days significantly decreased BNP-45 expression levels (p<0.05) compared with diabetic rats without treatment. Conclusion: Nanocurcumin may be beneficial in inhibiting the progression of diabetic cardiomyopathy by suppressing the expression of BNP-45.

Original languageEnglish
Pages (from-to)175-177
Number of pages3
JournalInternational Journal of Applied Pharmaceutics
Volume10
Issue numberSpecial Issue 1
DOIs
Publication statusPublished - 1 Dec 2018

Keywords

  • B-type natriuretic peptide-45
  • Nanocurcumin
  • Nicotinamide
  • Streptozotocin

Fingerprint Dive into the research topics of 'Effects of nanocurcumin in rats with diabetes induced with streptozotocin and nicotinamide: MRNA expression of B-type natriuretic peptide'. Together they form a unique fingerprint.

  • Cite this