Effects of continuous Hormone Replacement Therapy (HRT) on FSH, lipid profiles, blood chemistry, and skin thickness in menopausal women

Ali Baziad

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

This study was aimed to observe the effect of hormone replacement therapy (HRT) of estradiol 2 mg + 1 mg acetate noretisterone administered continuously on FSH hormone, lipid profile, blood chemistry, and skin thickness in menopausal women. The duration of HRT administration was 6 months. The subjects of the study were 35 menopausal women. The study was conducted from January 2001 to June 2001. After HRT administration of 6 months, a significant decrease of FSH was observed. No effect of HRT was found in bilirubin level; however, there was a slight increase of alkali phosphatase enzyme, and a signifcant increase in SGOT and SGPT. HRT caused a decrease of total cholesterol level and triglyceride level. In addition, a slight increase of LDL level and significant decrease of HDL level were observed. HRT administration with progesterone synthetic noretisterone showed an increase of skin collagen synthesis, which was indicated by the significant increase of skin thickness.

Original languageEnglish
Pages (from-to)97-103
Number of pages7
JournalMedical Journal of Indonesia
Volume11
Issue number2
DOIs
Publication statusPublished - 1 Apr 2002

Keywords

  • Blood chemistry
  • FSH
  • HRT
  • Lipid profile
  • Menopause
  • Skin thickness

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