Effectivity of dexamethasone in patients undergoing off-pump coronary artery bypass surgery

Dudy Arman Hanafy, I. Komang Adhi Parama Harta, I. Made Indra Prasetya, Pribadi Wiranda Busroh, Tri Wisesa Soetisna, Sugisman, Dicky Aligheri Wartono, Amin Tjubandi, Bagus Herlambang

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background: Based on our previous pilot study, systemic inflammatory response syndrome is more common in off-pump compared to on-pump coronary artery bypass. Therefore, we conducted a clinical trial of dexamethasone in patients undergoing off-pump coronary artery bypass. Methods: Sixty consecutive patients undergoing off-pump coronary artery bypass were enrolled from August 2018 to January 2019 and randomized to a dexamethasone or placebo group of 30 each. Clinical outcomes were analyzed. Results: There was a lower incidence of major adverse cardiac events in the dexamethasone group compared to the placebo group (17% versus 43%, p = 0.024). Clinical outcomes in the dexamethasone group were better than those in the placebo group, in terms of duration of mechanical ventilation (p = 0.029), intensive care unit stay (p = 0.028), hospital stay (p = 0.04), and vasoactive-inotropic score (p = 0.045). There were significant differences in inflammatory markers between the two groups: interleukin-6 (p = 0.0001), procalcitonin (p = 0.0001), and C-reactive protein (p = 0.0001) were lower in the dexamethasone group. There was a significant association between the incidence of major adverse cardiac events and both interleukin-6 (p = 0.005) and procalcitonin (p = 0.007). Conclusion: Preoperative dexamethasone in patients undergoing off-pump coronary artery bypass is effective in improving clinical outcomes and controlling the postoperative inflammatory reaction.

Original languageEnglish
Pages (from-to)388-393
Number of pages6
JournalAsian Cardiovascular and Thoracic Annals
Volume29
Issue number5
DOIs
Publication statusPublished - Jun 2021

Keywords

  • Anti-inflammatory agents
  • cardiopulmonary bypass
  • coronary artery bypass
  • dexamethasone
  • off-pump

Fingerprint

Dive into the research topics of 'Effectivity of dexamethasone in patients undergoing off-pump coronary artery bypass surgery'. Together they form a unique fingerprint.

Cite this