Effectiveness and acceptability of vitamin e and low-dose aspirin, alone or in combination, on Norplant-induced prolonged bleeding

Catherine D'Arcangues, Gilda Piaggio, Vivian Brache, Rim Ben Aissa, Catherine Hazelden, Rebeca Massai, Alain Pinol, Sri Bekti Subakir, Gu Su-Juan

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20 Citations (Scopus)

Abstract

A study (ISRCTN 77665712) was undertaken to test the effectiveness and the acceptability of vitamin E and low-dose aspirin, alone or in combination, as treatment for prolonged vaginal bleeding induced by Norplant. A total of 486 Norplant users who were requesting treatment for bleeding lasting longer than 7 days were enrolled in five centers: Beijing, China; Jakarta, Indonesia; Santiago, Chile; Santo Domingo, Dominican Republic; and Tunis, Tunisia. They were randomized to one of four different 10-day oral treatments: 200 mg vitamin E daily, 80 mg aspirin daily, both or a placebo. Treatment packs were designed to ensure blinding of both the subjects and the clinical staff. Neither vitamin E nor low-dose aspirin nor their combination was found to have any effect on reducing the length of the bleeding episode for which treatment was taken or on the vaginal bleeding patterns these women experienced during the year of follow-up.

Original languageEnglish
Pages (from-to)451-462
Number of pages12
JournalContraception
Volume70
Issue number6
DOIs
Publication statusPublished - 1 Dec 2004

Keywords

  • Acceptability
  • Aspirin
  • Norplant
  • Vaginal bleeding pattern
  • Vitamin E

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    D'Arcangues, C., Piaggio, G., Brache, V., Aissa, R. B., Hazelden, C., Massai, R., Pinol, A., Subakir, S. B., & Su-Juan, G. (2004). Effectiveness and acceptability of vitamin e and low-dose aspirin, alone or in combination, on Norplant-induced prolonged bleeding. Contraception, 70(6), 451-462. https://doi.org/10.1016/j.contraception.2004.05.012