Effectivenes of K2CO3 and KHCO3 as pore forming agents on floating drug delivery system hydrogel chitosan poly(N-vinyl pyrrolidone) semi-IPN: In vitro

Emil Budianto, A. Hidayatullah

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

This research was related to the preparation of Floating Drug Delivery System, consisted of hydrogel chitosan-poly(N-vinyl pyrrolidone) with chitosan compositions: PVP monomer 70:30 and formaldehyde 2% used as crosslinking agent. Two kinds of pore-forming agent were used in this research, which were potassium carbonate (K2CO3) and potassium bicarbonate (KHCO3) with variation of concentrations 0%, 1%, 2.5%, 5%, and 7.5% to the total mass of the initial reagents. The success of this research depends on the fast floating lag time and long floating time, as much as the percentage of the drug (amoxycillin) loading in the hydrogel and controlled drug release. FTIR characterization was used to analyze the changes of functional groups. Microscope Stereo Optical was used to identify the morphology of hydrogel and microcapsules. The best result showed that KHCO3 7.5% produced hydrogel which have the floating lag time of 14 minutes 2 seconds, floating time > 3 hours, 86% of encapsulation efficiency of amoxycillin trihydrate and dissolution capability up to 100%.

Original languageEnglish
Title of host publicationProceedings of the 3rd International Symposium on Current Progress in Mathematics and Sciences 2017, ISCPMS 2017
EditorsRatna Yuniati, Terry Mart, Ivandini T. Anggraningrum, Djoko Triyono, Kiki A. Sugeng
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735417410
DOIs
Publication statusPublished - 22 Oct 2018
Event3rd International Symposium on Current Progress in Mathematics and Sciences 2017, ISCPMS 2017 - Bali, Indonesia
Duration: 26 Jul 201727 Jul 2017

Publication series

NameAIP Conference Proceedings
Volume2023
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference3rd International Symposium on Current Progress in Mathematics and Sciences 2017, ISCPMS 2017
Country/TerritoryIndonesia
CityBali
Period26/07/1727/07/17

Keywords

  • FDDS
  • Floating
  • amoxycillin trihydrate
  • chitosan
  • hydrogel
  • poly(N-vinyl pyrrolidone)

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