Effectivenes of K2CO3 and KHCO3 as pore forming agents on floating drug delivery system hydrogel chitosan poly(N-vinyl pyrrolidone) semi-IPN: In vitro

E. Budianto; A. Hidayatullah

doi:10.1063/1.5064061

Effectivenes of K₂CO₃ and KHCO₃ as pore forming agents on floating drug delivery system hydrogel chitosan poly(N-vinyl pyrrolidone) semi-IPN: In vitro

E. Budianto, A. Hidayatullah

Department of Chemistry

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

This research was related to the preparation of Floating Drug Delivery System, consisted of hydrogel chitosan-poly(N-vinyl pyrrolidone) with chitosan compositions: PVP monomer 70:30 and formaldehyde 2% used as crosslinking agent. Two kinds of pore-forming agent were used in this research, which were potassium carbonate (K₂CO₃) and potassium bicarbonate (KHCO₃) with variation of concentrations 0%, 1%, 2.5%, 5%, and 7.5% to the total mass of the initial reagents. The success of this research depends on the fast floating lag time and long floating time, as much as the percentage of the drug (amoxycillin) loading in the hydrogel and controlled drug release. FTIR characterization was used to analyze the changes of functional groups. Microscope Stereo Optical was used to identify the morphology of hydrogel and microcapsules. The best result showed that KHCO₃ 7.5% produced hydrogel which have the floating lag time of 14 minutes 2 seconds, floating time > 3 hours, 86% of encapsulation efficiency of amoxycillin trihydrate and dissolution capability up to 100%.

Original language	English
Title of host publication	Proceedings of the 3rd International Symposium on Current Progress in Mathematics and Sciences 2017, ISCPMS 2017
Editors	Ratna Yuniati, Terry Mart, Ivandini T. Anggraningrum, Djoko Triyono, Kiki A. Sugeng
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735417410
DOIs	https://doi.org/10.1063/1.5064061
Publication status	Published - 22 Oct 2018
Event	3rd International Symposium on Current Progress in Mathematics and Sciences 2017, ISCPMS 2017 - Bali, Indonesia Duration: 26 Jul 2017 → 27 Jul 2017

Publication series

Name	AIP Conference Proceedings
Volume	2023
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	3rd International Symposium on Current Progress in Mathematics and Sciences 2017, ISCPMS 2017
Country/Territory	Indonesia
City	Bali
Period	26/07/17 → 27/07/17

Keywords

FDDS
Floating
amoxycillin trihydrate
chitosan
hydrogel
poly(N-vinyl pyrrolidone)

Access to Document

10.1063/1.5064061

Cite this

Budianto, E., & Hidayatullah, A. (2018). Effectivenes of K₂CO₃ and KHCO₃ as pore forming agents on floating drug delivery system hydrogel chitosan poly(N-vinyl pyrrolidone) semi-IPN: In vitro. In R. Yuniati, T. Mart, I. T. Anggraningrum, D. Triyono, & K. A. Sugeng (Eds.), Proceedings of the 3rd International Symposium on Current Progress in Mathematics and Sciences 2017, ISCPMS 2017 [020064] (AIP Conference Proceedings; Vol. 2023). American Institute of Physics Inc.. https://doi.org/10.1063/1.5064061

Budianto, E. ; Hidayatullah, A. / Effectivenes of K₂CO₃ and KHCO₃ as pore forming agents on floating drug delivery system hydrogel chitosan poly(N-vinyl pyrrolidone) semi-IPN : In vitro. Proceedings of the 3rd International Symposium on Current Progress in Mathematics and Sciences 2017, ISCPMS 2017. editor / Ratna Yuniati ; Terry Mart ; Ivandini T. Anggraningrum ; Djoko Triyono ; Kiki A. Sugeng. American Institute of Physics Inc., 2018. (AIP Conference Proceedings).

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title = "Effectivenes of K2CO3 and KHCO3 as pore forming agents on floating drug delivery system hydrogel chitosan poly(N-vinyl pyrrolidone) semi-IPN: In vitro",

abstract = "This research was related to the preparation of Floating Drug Delivery System, consisted of hydrogel chitosan-poly(N-vinyl pyrrolidone) with chitosan compositions: PVP monomer 70:30 and formaldehyde 2% used as crosslinking agent. Two kinds of pore-forming agent were used in this research, which were potassium carbonate (K2CO3) and potassium bicarbonate (KHCO3) with variation of concentrations 0%, 1%, 2.5%, 5%, and 7.5% to the total mass of the initial reagents. The success of this research depends on the fast floating lag time and long floating time, as much as the percentage of the drug (amoxycillin) loading in the hydrogel and controlled drug release. FTIR characterization was used to analyze the changes of functional groups. Microscope Stereo Optical was used to identify the morphology of hydrogel and microcapsules. The best result showed that KHCO3 7.5% produced hydrogel which have the floating lag time of 14 minutes 2 seconds, floating time > 3 hours, 86% of encapsulation efficiency of amoxycillin trihydrate and dissolution capability up to 100%.",

keywords = "FDDS, Floating, amoxycillin trihydrate, chitosan, hydrogel, poly(N-vinyl pyrrolidone)",

author = "E. Budianto and A. Hidayatullah",

note = "Funding Information: The Authors would like to thank Universitas Indonesia for supporting our research financially through Publikasi Internasional Terindeks untuk Tugas Akhir (PITTA) Grant. Publisher Copyright: {\textcopyright} 2018 Author(s).; 3rd International Symposium on Current Progress in Mathematics and Sciences 2017, ISCPMS 2017 ; Conference date: 26-07-2017 Through 27-07-2017",

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Budianto, E & Hidayatullah, A 2018, Effectivenes of K₂CO₃ and KHCO₃ as pore forming agents on floating drug delivery system hydrogel chitosan poly(N-vinyl pyrrolidone) semi-IPN: In vitro. in R Yuniati, T Mart, IT Anggraningrum, D Triyono & KA Sugeng (eds), Proceedings of the 3rd International Symposium on Current Progress in Mathematics and Sciences 2017, ISCPMS 2017., 020064, AIP Conference Proceedings, vol. 2023, American Institute of Physics Inc., 3rd International Symposium on Current Progress in Mathematics and Sciences 2017, ISCPMS 2017, Bali, Indonesia, 26/07/17. https://doi.org/10.1063/1.5064061

Effectivenes of K₂CO₃ and KHCO₃ as pore forming agents on floating drug delivery system hydrogel chitosan poly(N-vinyl pyrrolidone) semi-IPN: In vitro. / Budianto, E.; Hidayatullah, A.
Proceedings of the 3rd International Symposium on Current Progress in Mathematics and Sciences 2017, ISCPMS 2017. ed. / Ratna Yuniati; Terry Mart; Ivandini T. Anggraningrum; Djoko Triyono; Kiki A. Sugeng. American Institute of Physics Inc., 2018. 020064 (AIP Conference Proceedings; Vol. 2023).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - Effectivenes of K2CO3 and KHCO3 as pore forming agents on floating drug delivery system hydrogel chitosan poly(N-vinyl pyrrolidone) semi-IPN

T2 - 3rd International Symposium on Current Progress in Mathematics and Sciences 2017, ISCPMS 2017

AU - Budianto, E.

AU - Hidayatullah, A.

N1 - Funding Information: The Authors would like to thank Universitas Indonesia for supporting our research financially through Publikasi Internasional Terindeks untuk Tugas Akhir (PITTA) Grant. Publisher Copyright: © 2018 Author(s).

PY - 2018/10/22

Y1 - 2018/10/22

N2 - This research was related to the preparation of Floating Drug Delivery System, consisted of hydrogel chitosan-poly(N-vinyl pyrrolidone) with chitosan compositions: PVP monomer 70:30 and formaldehyde 2% used as crosslinking agent. Two kinds of pore-forming agent were used in this research, which were potassium carbonate (K2CO3) and potassium bicarbonate (KHCO3) with variation of concentrations 0%, 1%, 2.5%, 5%, and 7.5% to the total mass of the initial reagents. The success of this research depends on the fast floating lag time and long floating time, as much as the percentage of the drug (amoxycillin) loading in the hydrogel and controlled drug release. FTIR characterization was used to analyze the changes of functional groups. Microscope Stereo Optical was used to identify the morphology of hydrogel and microcapsules. The best result showed that KHCO3 7.5% produced hydrogel which have the floating lag time of 14 minutes 2 seconds, floating time > 3 hours, 86% of encapsulation efficiency of amoxycillin trihydrate and dissolution capability up to 100%.

AB - This research was related to the preparation of Floating Drug Delivery System, consisted of hydrogel chitosan-poly(N-vinyl pyrrolidone) with chitosan compositions: PVP monomer 70:30 and formaldehyde 2% used as crosslinking agent. Two kinds of pore-forming agent were used in this research, which were potassium carbonate (K2CO3) and potassium bicarbonate (KHCO3) with variation of concentrations 0%, 1%, 2.5%, 5%, and 7.5% to the total mass of the initial reagents. The success of this research depends on the fast floating lag time and long floating time, as much as the percentage of the drug (amoxycillin) loading in the hydrogel and controlled drug release. FTIR characterization was used to analyze the changes of functional groups. Microscope Stereo Optical was used to identify the morphology of hydrogel and microcapsules. The best result showed that KHCO3 7.5% produced hydrogel which have the floating lag time of 14 minutes 2 seconds, floating time > 3 hours, 86% of encapsulation efficiency of amoxycillin trihydrate and dissolution capability up to 100%.

KW - FDDS

KW - Floating

KW - amoxycillin trihydrate

KW - chitosan

KW - hydrogel

KW - poly(N-vinyl pyrrolidone)

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BT - Proceedings of the 3rd International Symposium on Current Progress in Mathematics and Sciences 2017, ISCPMS 2017

A2 - Yuniati, Ratna

A2 - Mart, Terry

A2 - Anggraningrum, Ivandini T.

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A2 - Sugeng, Kiki A.

PB - American Institute of Physics Inc.

Y2 - 26 July 2017 through 27 July 2017

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Budianto E, Hidayatullah A. Effectivenes of K₂CO₃ and KHCO₃ as pore forming agents on floating drug delivery system hydrogel chitosan poly(N-vinyl pyrrolidone) semi-IPN: In vitro. In Yuniati R, Mart T, Anggraningrum IT, Triyono D, Sugeng KA, editors, Proceedings of the 3rd International Symposium on Current Progress in Mathematics and Sciences 2017, ISCPMS 2017. American Institute of Physics Inc. 2018. 020064. (AIP Conference Proceedings). doi: 10.1063/1.5064061