Effect of vitamin A supplementation on measles vaccination in nine-month-old infants

R. D. Semba; A. Akib; J. Beeler; Z. Munasir; D. Permaesih; Muherdiyantiningsih; Komala; S. Martuti; Muhilal

doi:10.1016/S0033-3506(97)00042-5

Effect of vitamin A supplementation on measles vaccination in nine-month-old infants

R. D. Semba, A. Akib, J. Beeler, Z. Munasir, D. Permaesih, Muherdiyantiningsih, Komala, S. Martuti, Muhilal

Department of Pediatric

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Objective: Childhood immunization programs have been suggested as an infrastructure to deliver vitamin A supplements to children in developing countries. The effects of giving vitamin A, a potent immune enhancer, with measles immunization to nine-month-old infants is unknown. Methods: A randomized, double-masked, placebo-controlled clinical trial of vitamin A, 100,000 IU at the time of standard titer Schwarz measles immunization was conducted with nine-month-old infants in Bogor District, West Java, Indonesia. Antibody titers to measles were measured at baseline and one and six months following immunization. Results: 394 infants received measles immunization, and 37 infants (9.4%) had baseline antibody titers > 1:120, which is consistent with previous natural measles infection. Of the remaining infants, 98.8% seroconverted to measles, and 99.3% had titers consistent with protection against measles six months postimmunization. Seroconversion rates were similar in vitamin A and placebo treatment groups. Conclusion: High dose vitamin A supplementation can be given without reducing seroconversion to standard titer Schwarz measles immunization in nine-month-old infants.

Original language	English
Pages (from-to)	245-247
Number of pages	3
Journal	Public Health
Volume	111
Issue number	4
DOIs	https://doi.org/10.1016/S0033-3506(97)00042-5
Publication status	Published - 1997

Keywords

Indonesia
Measles
Retinol
Vaccination
Vitamin A

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0033-3506(97)00042-5

Cite this

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title = "Effect of vitamin A supplementation on measles vaccination in nine-month-old infants",

abstract = "Objective: Childhood immunization programs have been suggested as an infrastructure to deliver vitamin A supplements to children in developing countries. The effects of giving vitamin A, a potent immune enhancer, with measles immunization to nine-month-old infants is unknown. Methods: A randomized, double-masked, placebo-controlled clinical trial of vitamin A, 100,000 IU at the time of standard titer Schwarz measles immunization was conducted with nine-month-old infants in Bogor District, West Java, Indonesia. Antibody titers to measles were measured at baseline and one and six months following immunization. Results: 394 infants received measles immunization, and 37 infants (9.4%) had baseline antibody titers > 1:120, which is consistent with previous natural measles infection. Of the remaining infants, 98.8% seroconverted to measles, and 99.3% had titers consistent with protection against measles six months postimmunization. Seroconversion rates were similar in vitamin A and placebo treatment groups. Conclusion: High dose vitamin A supplementation can be given without reducing seroconversion to standard titer Schwarz measles immunization in nine-month-old infants.",

keywords = "Indonesia, Measles, Retinol, Vaccination, Vitamin A",

author = "Semba, {R. D.} and A. Akib and J. Beeler and Z. Munasir and D. Permaesih and Muherdiyantiningsih and Komala and S. Martuti and Muhilal",

note = "Funding Information: This study was supported by grants from the National Institutes of Health (AI35143, HD30042), the Thrasher Research Fund, the WHO Expanded Programme on Immunization, and the Office of Nutrition, Bureau for Science and Technology, US Agency for International Development (Cooperative Agreement DAN-0045-A-5094-00). The authors wish to acknowledge the staff of the Nutrition Research and Development Center for the field support, Biocine Sclavo, Siena, Italy, for donation of measles vaccine, and Task Force Sight and Life, Basel, Switzerland, for donation of vitamin A and placebo capsules. Technical support was provided by Susette Audet.",

year = "1997",

doi = "10.1016/S0033-3506(97)00042-5",

language = "English",

volume = "111",

pages = "245--247",

journal = "Public Health",

issn = "0033-3506",

publisher = "Elsevier B.V.",

number = "4",

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TY - JOUR

T1 - Effect of vitamin A supplementation on measles vaccination in nine-month-old infants

AU - Semba, R. D.

AU - Akib, A.

AU - Beeler, J.

AU - Munasir, Z.

AU - Permaesih, D.

AU - Muherdiyantiningsih,

AU - Komala,

AU - Martuti, S.

AU - Muhilal,

N1 - Funding Information: This study was supported by grants from the National Institutes of Health (AI35143, HD30042), the Thrasher Research Fund, the WHO Expanded Programme on Immunization, and the Office of Nutrition, Bureau for Science and Technology, US Agency for International Development (Cooperative Agreement DAN-0045-A-5094-00). The authors wish to acknowledge the staff of the Nutrition Research and Development Center for the field support, Biocine Sclavo, Siena, Italy, for donation of measles vaccine, and Task Force Sight and Life, Basel, Switzerland, for donation of vitamin A and placebo capsules. Technical support was provided by Susette Audet.

PY - 1997

Y1 - 1997

N2 - Objective: Childhood immunization programs have been suggested as an infrastructure to deliver vitamin A supplements to children in developing countries. The effects of giving vitamin A, a potent immune enhancer, with measles immunization to nine-month-old infants is unknown. Methods: A randomized, double-masked, placebo-controlled clinical trial of vitamin A, 100,000 IU at the time of standard titer Schwarz measles immunization was conducted with nine-month-old infants in Bogor District, West Java, Indonesia. Antibody titers to measles were measured at baseline and one and six months following immunization. Results: 394 infants received measles immunization, and 37 infants (9.4%) had baseline antibody titers > 1:120, which is consistent with previous natural measles infection. Of the remaining infants, 98.8% seroconverted to measles, and 99.3% had titers consistent with protection against measles six months postimmunization. Seroconversion rates were similar in vitamin A and placebo treatment groups. Conclusion: High dose vitamin A supplementation can be given without reducing seroconversion to standard titer Schwarz measles immunization in nine-month-old infants.

AB - Objective: Childhood immunization programs have been suggested as an infrastructure to deliver vitamin A supplements to children in developing countries. The effects of giving vitamin A, a potent immune enhancer, with measles immunization to nine-month-old infants is unknown. Methods: A randomized, double-masked, placebo-controlled clinical trial of vitamin A, 100,000 IU at the time of standard titer Schwarz measles immunization was conducted with nine-month-old infants in Bogor District, West Java, Indonesia. Antibody titers to measles were measured at baseline and one and six months following immunization. Results: 394 infants received measles immunization, and 37 infants (9.4%) had baseline antibody titers > 1:120, which is consistent with previous natural measles infection. Of the remaining infants, 98.8% seroconverted to measles, and 99.3% had titers consistent with protection against measles six months postimmunization. Seroconversion rates were similar in vitamin A and placebo treatment groups. Conclusion: High dose vitamin A supplementation can be given without reducing seroconversion to standard titer Schwarz measles immunization in nine-month-old infants.

KW - Indonesia

KW - Measles

KW - Retinol

KW - Vaccination

KW - Vitamin A

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AN - SCOPUS:0030762712

SN - 0033-3506

VL - 111

SP - 245

EP - 247

JO - Public Health

JF - Public Health

IS - 4

ER -

Effect of vitamin A supplementation on measles vaccination in nine-month-old infants

Abstract

Keywords

UN SDGs

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