Effect of vitamin A supplementation on measles vaccination in nine-month-old infants

R. D. Semba, A. Akib, J. Beeler, Z. Munasir, D. Permaesih, Muherdiyantiningsih, Komala, S. Martuti, Muhilal

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)


Objective: Childhood immunization programs have been suggested as an infrastructure to deliver vitamin A supplements to children in developing countries. The effects of giving vitamin A, a potent immune enhancer, with measles immunization to nine-month-old infants is unknown. Methods: A randomized, double-masked, placebo-controlled clinical trial of vitamin A, 100,000 IU at the time of standard titer Schwarz measles immunization was conducted with nine-month-old infants in Bogor District, West Java, Indonesia. Antibody titers to measles were measured at baseline and one and six months following immunization. Results: 394 infants received measles immunization, and 37 infants (9.4%) had baseline antibody titers > 1:120, which is consistent with previous natural measles infection. Of the remaining infants, 98.8% seroconverted to measles, and 99.3% had titers consistent with protection against measles six months postimmunization. Seroconversion rates were similar in vitamin A and placebo treatment groups. Conclusion: High dose vitamin A supplementation can be given without reducing seroconversion to standard titer Schwarz measles immunization in nine-month-old infants.

Original languageEnglish
Pages (from-to)245-247
Number of pages3
JournalPublic Health
Issue number4
Publication statusPublished - 1997


  • Indonesia
  • Measles
  • Retinol
  • Vaccination
  • Vitamin A


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